Risk stratification of patients with right-sided colorectal cancer based on the tumor-infiltrating M1 macrophage.

Autor:	Lim DM; Interdisciplinary Program of Genomic Data Science, Pusan National University Yangsan, Republic of Korea., Kang J; Medical Research Institute, Pusan National University Busan, Republic of Korea., Woo SY; Department of Convergence Medicine, School of Medicine, Pusan National University Yangsan, Republic of Korea., Choi HS; Department of Convergence Medicine, School of Medicine, Pusan National University Yangsan, Republic of Korea., Kwon M; Department of Convergence Medicine, School of Medicine, Pusan National University Yangsan, Republic of Korea., Kim J; Department of Convergence Medicine, School of Medicine, Pusan National University Yangsan, Republic of Korea., Park HR; Department of Oral Pathology, School of Dentistry, Pusan National University Yangsan, Republic of Korea., Jung K; Department of Anatomy and Cell Biology and Department of Biomedical Sciences, Seoul National University College of Medicine Seoul, Republic of Korea., Baryawno N; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet Stockholm 17177, Sweden., Kim HS; Department of Oral Biochemistry, School of Dentistry, Pusan National University Yangsan 50612, Republic of Korea.; Dental and Life Science Institute, School of Dentistry, Pusan National University Yangsan 50612, Republic of Korea., Lee D; Department of Convergence Medicine, School of Medicine, Pusan National University Yangsan, Republic of Korea., Kim YH; Department of Anatomy, School of Medicine, Pusan National University Yangsan, Republic of Korea.; Department of Biomedical Informatics, School of Medicine, Pusan National University Yangsan, Republic of Korea.; Dental and Life Science Institute, School of Dentistry, Pusan National University Yangsan 50612, Republic of Korea.
Jazyk:	angličtina
Zdroj:	American journal of cancer research [Am J Cancer Res] 2022 Dec 15; Vol. 12 (12), pp. 5532-5551. Date of Electronic Publication: 2022 Dec 15 (Print Publication: 2022).
Abstrakt:	The homing of M1 and M2 macrophages may play distinct roles in the tumor microenvironment (TME). However, these roles of macrophages in the TME remain unclear. We downloaded RNA sequencing data from The Cancer Genome Atlas (TCGA) database for patients with CRC. Subsequently, Kaplan-Meier survival curves were generated to assess the differential infiltration of M1 and M2 macrophages based on CRC location. Differentially expressed gene (DEG) and functional analyses were performed to screen the roles of DEGs. Critical prognostic genes were identified using least absolute shrinkage and selection operator regression. The risk scores were calculated for each patient. In patients with right-sided CRC, reduced M1 macrophage infiltration was associated with poor prognosis. M1 macrophage infiltration positively correlated with CD8+ T cell infiltration. A risk model was developed and validated for performance using GSE103479 and GSE72970. Nine genes were identified as independent prognostic genes that could be potential biomarkers for effectively predicting survival in patients with right-sided CRC. Kaplan-Meier curves for overall survival and progression-free survival analyses revealed that the high-risk group of patients with right-sided CRC had a poor prognosis. This novel M1 macrophage-related risk model may provide a gene signature for predicting the survival outcomes of patients with right-sided CRC and facilitate further studies examining the relationship between infiltration of M1 macrophages and the prognosis of such patients. Competing Interests: None. (AJCR Copyright © 2022.)
Databáze:	MEDLINE
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