High-Fat Diet as a Risk Factor for Breast Cancer: A Meta-Analysis.

Autor:	Uhomoibhi TO; Lombardi Comprehensive Cancer Center, Georgetown University/University of the District of Columbia, Washington D.C, USA., Okobi TJ; Internal Medicine, BronxCare Health System, New York, USA., Okobi OE; Family Medicine, Arizona State University, Tempe, USA.; Family Medicine, Lakeside Medical Center, Belle Glade, USA., Koko JO; Family and Community Medicine, University of Jos, Jos, NGA., Uhomoibhi O; Internal Medicine, Georgetown University, Bronx, USA., Igbinosun OE; Haemato-Oncology, University of Benin Teaching Hospital, Benin City, NGA., Ehibor UD; Family Medicine, University of Benin Teaching Hospital, Benin City, NGA., Boms MG; Clinical Research, University of Alabama at Birmingham, Birmingham, USA., Abdulgaffar RA; Communicable Disease Control, Alberta Health Services, Calgary, CAN., Hammed BL; Family Medicine, Plato Hospital, Lagos, NGA., Ibeanu C; Pediatrics, V.N. Karazin Kharkiv National University, Kharkiv, UKR., Segun EO; School of Biological Sciences & Applied Chemistry, Seneca College, Toronto, CAN., Adeosun AA; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, USA., Evbayekha EO; Internal Medicine, St. Luke's Hospital, Chesterfield, USA., Alex KB; Faculty of Medicine, University of London, London, GBR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Dec 08; Vol. 14 (12), pp. e32309. Date of Electronic Publication: 2022 Dec 08 (Print Publication: 2022).
DOI:	10.7759/cureus.32309
Abstrakt:	High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and progression of breast cancer is essential, as it will enable us to identify the role of dietary modification in preventing and managing the disease. The impact of a high-fat diet (HFD) on the development of breast cancer in humans has yet to be fully explained, as very few human studies are available to effectively analyze the effect fatty food has on breast cancer development. This meta-analysis, therefore, seeks to determine the strength of association, if any, between HFD and an increased risk of breast cancer development. This research will help inform good eating habits, potentially reducing the disease's incidence and outcome. This meta-analysis examined eight (8) papers from various nations examining the effect of a high-fat diet as a risk factor for breast cancer development between 2010 and 2020. The study employed the multivariable-adjusted hazard ratio (H.R.), odds ratio (OR), or relative risk (R.R.) from the studies. Breast cancer cases were histologically and radiologically confirmed in the studies evaluated, and validated food frequency questionnaires were used to assess their dietary patterns. This metanalysis study found a substantial link between a high-fat diet and an increased risk of breast cancer, with statistically significant results (I 2 = 93.38%, p0.05). Changes in dietary fat consumption may thus help mitigate some of the unfavorable consequences of breast cancer and survival. Even if further research is needed to support this assertion, the findings are compelling enough to advocate for low-fat, healthy diets to avoid breast cancer. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Uhomoibhi et al.)
Databáze:	MEDLINE
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