Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety.

Autor: Mahmoud KY; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Elhesaisy NA; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Rashed AR; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Mikhael ES; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Fadl MI; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Elsadek MS; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Mohamed MA; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Mostafa MA; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Hassan MA; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Halema OM; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Elnemer YH; Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt., Swidan SA; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, 11837, Cairo, Egypt. shady.swidan@bue.edu.eg.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 10; Vol. 13 (1), pp. 510. Date of Electronic Publication: 2023 Jan 10.
DOI: 10.1038/s41598-023-27665-6
Abstrakt: Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9 nm, polydispersity index of 0.466 ± 0.023, zeta potential of - 17.5 ± 0.01 mV, and encapsulation efficiency % of 92.5 ± 1.9%. In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. Behavioral testing demonstrated the superiority of QRC loaded polymeric nanocapsules administered intranasally compared to QRC dispersion administered both orally and intranasally. The prepared QRC loaded polymeric nanocapsules also demonstrated good safety profile with high tolerability.
(© 2023. The Author(s).)
Databáze: MEDLINE
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