| Autor: |
Kartsova LA; Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russia., Bessonova EA; Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russia., Deev VA; Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russia., Kolobova EA; Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russia.; The Federal State Institute of Public Health 'The Nikiforov Russian Center of Emergency and Radiation Medicine', The Ministry of Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters, St. Petersburg, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in analytical chemistry [Crit Rev Anal Chem] 2024; Vol. 54 (7), pp. 2110-2133. Date of Electronic Publication: 2023 Jan 10. |
| DOI: |
10.1080/10408347.2022.2156770 |
| Abstrakt: |
Endometriosis has a wide range of clinical manifestations, and the disease course is unpredictable, making the diagnosis a challenging task. Despite significant advances in the pathophysiology of endometriosis and various proposed theories, the exact etiology is not fully understood and is still unknown. The most commonly used biomarker of endometriosis is CA-125, however, it is nonspecific and is applied for cancers diagnosis. Therefore, the development of reliable noninvasive diagnostic tests for the early diagnosis of endometriosis remains one of the top priorities. Omics technologies are very promising approaches for constructing diagnostic models and biomarker discovery. Their use can greatly facilitate the study of such a complex disease as endometriosis. Nowadays, powerful analytical platforms commonly used in omics, such as gas and liquid chromatography with mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, have proven to be a promising tools for biomarker discovery. The aim of this review is to summarize the various features of the analytical approaches, practical challenges and features of gas and liquid chromatography with MS and NMR spectroscopy (including sample processing protocols, technological advancements, and methodology) used for profiling of metabolites, lipids, peptides and proteins in physiological fluids and tissues from patients with endometriosis. In addition, this report devotes special attention to the issue of how comprehensive analyses of these profiles can effectively contribute to the study of endometriosis. The search query included reports published between 2012 and 2022 years in PubMed, Web-of-Science, SCOPUS, Science Direct. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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