The C24:0 Sulfatide Isoform as an Important Molecule in Type 1 Diabetes.
| Autor: | Buschard K; The Bartholin Institute, Department of Pathology, Rigshospitalet, 2100 Copenhagen, Denmark., Antvorskov JC; The Bartholin Institute, Department of Pathology, Rigshospitalet, 2100 Copenhagen, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2022 Dec 27; Vol. 27 (12), pp. 331. |
| DOI: | 10.31083/j.fbl2712331 |
| Abstrakt: | Particular molecules play pivotal roles in the pathogenesis of many autoimmune diseases. We suggest that the C24:0 sulfatide isoform may influence the development of type 1 diabetes (T1D). C24:0 sulfatide is a sphingolipid with a long carbon-atom chain. A C16:0 sulfatide isoform is also present in the insulin-producing beta cells of the islets of Langerhans. The C16:0 isoform exhibits chaperone activity and plays an important role in insulin production. In contrast, the C24:0 isoform may suppress the autoimmune attacks on beta cells that lead to T1D. Sphingolipid levels are reduced in individuals who later develop T1D but could be increased via dietary supplements or medication. Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s). Published by IMR Press.) |
| Databáze: | MEDLINE |
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