Rapid prediction of secondary neurologic decline after traumatic brain injury: a data analytic approach.

Autor: Podell J; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.; Department of Neurology, University of Maryland School of Medicine, Baltimore, USA., Yang S; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.; Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA., Miller S; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Felix R; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Tripathi H; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Parikh G; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.; Department of Neurology, University of Maryland School of Medicine, Baltimore, USA., Miller C; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Chen H; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA., Kuo YM; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Lin CY; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA., Hu P; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.; Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA., Badjatia N; Program in Trauma, Shock Trauma Neurocritical Care, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA. nbadjatia@som.umaryland.edu.; Department of Neurology, University of Maryland School of Medicine, Baltimore, USA. nbadjatia@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 09; Vol. 13 (1), pp. 403. Date of Electronic Publication: 2023 Jan 09.
DOI: 10.1038/s41598-022-26318-4
Abstrakt: Secondary neurologic decline (ND) after traumatic brain injury (TBI) is independently associated with outcome, but robust predictors of ND are lacking. In this retrospective analysis of consecutive isolated TBI admissions to the R. Adams Cowley Shock Trauma Center between November 2015 and June 2018, we aimed to develop a triage decision support tool to quantify risk for early ND. Three machine learning models based on clinical, physiologic, or combined characteristics from the first hour of hospital resuscitation were created. Among 905 TBI cases, 165 (18%) experienced one or more ND events (130 clinical, 51 neurosurgical, and 54 radiographic) within 48 h of presentation. In the prediction of ND, the clinical plus physiologic data model performed similarly to the physiologic only model, with concordance indices of 0.85 (0.824-0.877) and 0.84 (0.812-0.868), respectively. Both outperformed the clinical only model, which had a concordance index of 0.72 (0.688-0.759). This preliminary work suggests that a data-driven approach utilizing physiologic and basic clinical data from the first hour of resuscitation after TBI has the potential to serve as a decision support tool for clinicians seeking to identify patients at high or low risk for ND.
(© 2023. The Author(s).)
Databáze: MEDLINE
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