Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma.

Autor:	Hassan WA; Department of Pathology, Faculty of Medicine, Suez Canal University, El Sheikh Zayed, Egypt.; Department of Basic Sciences, College of Medicine, Suliman Al Rajhi University, Al Bukairiyah, Saudi Arabia., ElBanna AK; Department of Basic Sciences, College of Medicine, Suliman Al Rajhi University, Al Bukairiyah, Saudi Arabia.; Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Noufal N; Department of Pathology, Faculty of Medicine, Suez Canal University, El Sheikh Zayed, Egypt.; Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia., El-Assmy M; Department of Clinical Sciences, Suliman Al Rajhi University, Bukayriah, Saudi Arabia., Lotfy H; Department of Basic Sciences, College of Medicine, Suliman Al Rajhi University, Al Bukairiyah, Saudi Arabia.; Department of Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Ali RI; Department of Pathology, College of Medicine, Jouf University, Al-Jawf, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Journal of pathology and translational medicine [J Pathol Transl Med] 2023 Mar; Vol. 57 (2), pp. 88-94. Date of Electronic Publication: 2023 Jan 10.
DOI:	10.4132/jptm.2022.11.06
Abstrakt:	Background: Tumor-infiltrating neutrophils and lymphocytes play essential roles in promoting or combating various neoplasms. This study aimed to investigate the association between tumor-infiltrating neutrophils and lymphocytes and the neutrophil-to-lymphocyte ratio in the progression of urothelial carcinoma. Methods: A total of 106 patients diagnosed with urothelial carcinoma were was. Pathological examination for tumor grade and stage and for tumor-infiltrating neutrophils, both CD4 and CD8+ T lymphocytes, as well as the neutrophil- to-lymphocyte ratio were evaluated. Results: The presence of neutrophils and the neutrophil-to-lymphocyte ratio correlated with high-grade urothelial neoplasms. In both low- and high-grade tumors, the lymphocytes increased during progression from a non-invasive neoplasm to an early-invasive neoplasm. CD8+ T lymphocytes increased in low-grade non-muscle-invasive tumors compared to non-invasive tumors. Additionally, there was a significant decrease in CD8+ T lymphocytes during progression to muscle-invasive tumors. Conclusions: Our results suggest that tumor-infiltrating neutrophils and CD8+ T lymphocytes have a significant effect on tumor grade and progression.
Databáze:	MEDLINE
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