Safety and Effects of a Commercial Ozone Foam Preparation on Endometrial Environment and Fertility of Mares.

Autor: Donato GG; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy. Electronic address: gianguido.donato@unito.it., Appino S; Dipartimento di Medicina Veterinaria, Università di Sassari, Sassari, Italy., Bertero A; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy., Poletto ML; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy., Nebbia P; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy., Robino P; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy., Varello K; Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Torino, Italy., Bozzetta E; Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Torino, Italy., Vincenti L; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy., Nervo T; Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco, Italy.
Jazyk: angličtina
Zdroj: Journal of equine veterinary science [J Equine Vet Sci] 2023 Feb; Vol. 121, pp. 104222. Date of Electronic Publication: 2023 Jan 06.
DOI: 10.1016/j.jevs.2023.104222
Abstrakt: Mares' subfertility represents a complex diagnostic and therapeutic challenge and both clinical and subclinical endometritis are considered major causes of impaired fertility. Thanks to its properties, ozone has a big potential as a treatment for equine endometritis. Therefore, the aim of this study is to describe the safety and the effects on endometrium and reproductive parameters of mares of a commercial ozone foam preparation (Riger Spray®). Twenty-four mares were treated during estrus: ozone group with an intrauterine instillation of ozone foam preparation (OG, n=16) and control group with 20 ml of lactated Ringer's solution (CG, n=8). Samples for endometrial cytology were collected before the ozone treatment (T0), after 24 h (T1), after one week (T2), two weeks (T3), and when the subsequent estrous phase was detected (T4). Furthermore, samples for histological examination and uterine swab for bacteriological examination were collected at T0 and T4. At T1, a statistically significant increase of endometrial inflammation in the OG mares compared to T0 (P<.05) and to CG at same time point (P<.05) was observed, but it was already resolved at T2. No differences in endometrial inflammation in CG, biopsy grade before and after the treatment in the two groups, number of mares pregnant at the end of the season and number of mares pregnant at the first cycle were observed. However, the number of inseminations required for pregnancy tended to be lower (P=.0711) in the OG (1.69±0.06) than in CG mares (2.60±0.89).
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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