Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain.

Autor: Rinta-Jaskari MM; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Naillat F; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Ruotsalainen HJ; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Koivunen JT; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Sasaki T; Department of Biochemistry II, Faculty of Medicine, Oita University, Japan., Pietilä I; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland; Currently: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden., Elamaa HP; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Kaur I; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Manninen A; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Vainio SJ; Infotech Oulu, Kvantum Institute; Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland., Pihlajaniemi TA; Oulu Center of Cell-Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland. Electronic address: taina.pihlajaniemi@oulu.fi.
Jazyk: angličtina
Zdroj: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2023 Jan; Vol. 115, pp. 139-159. Date of Electronic Publication: 2023 Jan 06.
DOI: 10.1016/j.matbio.2023.01.001
Abstrakt: Collagen XVIII (ColXVIII) is a component of the extracellular matrix implicated in embryogenesis and control of tissue homoeostasis. We now provide evidence that ColXVIII has a specific role in renal branching morphogenesis as observed in analyses of total and isoform-specific knockout embryos and mice. The expression of the short and the two longer isoforms differ temporally and spatially during renal development. The lack of ColXVIII or its specific isoforms lead to congenital defects in the 3D patterning of the ureteric tree where the short isoform plays a prominent role. Moreover, the ex vivo data suggests that ColXVIII is involved in the kidney epithelial tree patterning via its N-terminal domains, and especially the Thrombospondin-1-like domain common to all isoforms. This morphogenetic function likely involves integrins expressed in the ureteric epithelium. Altogether, the results point to an important role for ColXVIII in the matrix-integrin-mediated functions regulating renal development.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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