Radioactive versus normal stent insertion for malignant hilar obstruction: a meta-analysis.

Autor: Chen ZK; Department of Intervention, Affiliated Hospital of Gansu Medical College, Pingliang, China., Li DL; Gansu Medical College, Pingliang, China., Du JJ; Department of Intervention, Affiliated Hospital of Gansu Medical College, Pingliang, China., She JX; Department of Intervention, Affiliated Hospital of Gansu Medical College, Pingliang, China., Meng J; Department of Radiology, The First people's Hospital Hua Ting, Pingliang, China., Fan J; Department of Radiology Affiliated Hospital of Gansu Medical College, Pingliang, China.
Jazyk: angličtina
Zdroj: Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy [Minim Invasive Ther Allied Technol] 2023 Apr; Vol. 32 (2), pp. 47-55. Date of Electronic Publication: 2023 Jan 09.
DOI: 10.1080/13645706.2022.2164697
Abstrakt: Purpose: This meta-analysis was designed for examining the relative clinical safety and efficacy of normal stent (NS) and radioactive stent (RS) insertion in malignant hilar obstruction (MHO) patients.
Material and Methods: Relevant studies published as of March 2022 were identified through searches of the Medline, Embase, Wanfang, and CNKI databases, and the pooled results of these studies were then analyzed.
Results: Eight studies including 258 and 247 patients that underwent NS and RS insertion, respectively, were incorporated into this meta-analysis. RS insertion was found to be associated with significant improvements in functional successful rate ( p  = 0.04), Δaspertate aminotransferase (AST, p  = 0.0004), Δalanine aminotransferase (ALT, p  = 0.002), stent patency ( p  < 0.00001), stent re-obstruction rate ( p  = 0.03), and OS ( p  < 0.00001) outcomes as compared to those associated with NS insertion. No differences in Δtotal bilirubin (TBIL, p  = 0.38), cholangeitis rate ( p  = 0.45), cholecystitis rate ( p  = 0.84), or hemorrhage rate ( p  = 0.87) were observed when comparing patients that underwent RS and NS insertion. Substantial publication bias was observed for endpoints of cholecystitis and hemorrhage.
Conclusions: These results suggest that relative to NS insertion, RS insertion can effectively prolong stent patency and OS in MHO cases.
Databáze: MEDLINE
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