Fatigue after COVID-19 in non-hospitalized patients according to sex.

Autor: Mazurkiewicz I; Department of Neurology, University Hospital in Krakow, Krakow, Poland., Chatys-Bogacka Z; Department of Neurology, University Hospital in Krakow, Krakow, Poland.; Department of Neurology, Jagiellonian University Medical College, Krakow, Poland., Slowik J; Department of Periodontology, Preventive Dentistry and Oral Medicine, Institute of Dentistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland., Klich-Raczka A; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.; Department of Internal Medicine and Geriatrics, University Hospital in Krakow, Krakow, Poland., Fedyk-Lukasik M; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland., Slowik A; Department of Neurology, University Hospital in Krakow, Krakow, Poland.; Department of Neurology, Jagiellonian University Medical College, Krakow, Poland., Wnuk M; Department of Neurology, University Hospital in Krakow, Krakow, Poland.; Department of Neurology, Jagiellonian University Medical College, Krakow, Poland., Drabik L; Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2023 Feb; Vol. 13 (2), pp. e2849. Date of Electronic Publication: 2023 Jan 09.
DOI: 10.1002/brb3.2849
Abstrakt: Background: Limited evidence exists on sex differences in post-COVID fatigue among non-hospitalized patients. Therefore, aim of the study was to evaluate the course of chronic fatigue symptoms in non-hospitalized subjects with the SARS-CoV-2 infection, according to sex.
Methods: Patients and staff from the University Hospital in Krakow anonymously and retrospectively completed neuropsychological questionnaire that included eight symptoms of chronic fatigue syndrome. The presence of these symptoms was assessed before COVID-19 and 0-4, 4-12, and >12 weeks postinfection. The inclusion criteria were as follows: age 18 or more years, >12 weeks since the onset of the SARS-CoV-2 infection, and diagnosis confirmed by the RT-PCR from anasopharyngeal swab.
Results: We included 303 patients (79.53% women, 47.52% medical personnel) assessed retrospectively after a median of 30 (interquartile range: 23-35) weeks since the onset of symptoms. A higher prevalence of at least one chronic fatigue symptom was found in females in all time intervals after the onset of COVID-19 compared to males (p < .036). Women, compared to men, more often experienced persistent fatigue, not caused by effort and persisting after rest (for <4 weeks, odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.13-4.73; for 4-12 weeks, OR = 1.95, 95% CI: 1.06-3.61), non-restorative sleep (for <4 weeks, OR = 2.17, 95% CI: 1.23-3.81; for >12 weeks, OR = 1.95, 95% CI: 1.03-3.71), and sore throat (for <4 weeks, OR = 1.97, 95% CI: 1.03-3.78; for 4-12 weeks, OR = 2.76, 95% CI: 1.05-7.27). Sex differences in headache, arthralgia, and prolonged postexercise fatigue were observed only during the first 4 weeks (OR = 2.59, 95% CI: 1.45-4.60, OR = 2.97, 95% CI: 1.02-8.64, and OR = 1.87, 95% CI: 1.01-3.51, respectively). There were no differences between women and men in myalgia and self-reported lymph node enlargement.
Conclusions: The course of post-COVID fatigue differs significantly between sexes in non-hospitalized individuals with COVID-19, with women more often suffering from persistent fatigue, not caused by effort and persisting after rest, non-restorative sleep, and sore throat.
(© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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