Gut Microbiota Linked with Reduced Fear of Humans in Red Junglefowl Has Implications for Early Domestication.

Autor: Puetz LC; Center for Evolutionary Hologenomics GLOBE Institute University of Copenhagen Copenhagen 1353 Denmark., Delmont TO; Génomique Métabolique Genoscope Institut François Jacob CEA CNRS Univ Evry Université Paris-Saclay Evry 91057 France., Aizpurua O; Center for Evolutionary Hologenomics GLOBE Institute University of Copenhagen Copenhagen 1353 Denmark., Guo C; China National GeneBank BGI-Shenzhen Shenzhen 518083 China., Zhang G; China National GeneBank BGI-Shenzhen Shenzhen 518083 China.; Villum Center for Biodiversity Genomics, Section for Ecology and Evolution, Department of Biology University of Copenhagen Copenhagen 2100 Denmark.; State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China.; Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China., Katajamaa R; IFM Biology, AVIAN Behaviour Genomics and Physiology Group Linköping University Linköping 58330 Sweden., Jensen P; IFM Biology, AVIAN Behaviour Genomics and Physiology Group Linköping University Linköping 58330 Sweden., Gilbert MTP; Center for Evolutionary Hologenomics GLOBE Institute University of Copenhagen Copenhagen 1353 Denmark.; Department of Natural History, NTNU University Museum Norwegian University of Science and Technology (NTNU) Trondheim 7491 Norway.
Jazyk: angličtina
Zdroj: Advanced genetics (Hoboken, N.J.) [Adv Genet (Hoboken)] 2021 Dec 09; Vol. 2 (4), pp. 2100018. Date of Electronic Publication: 2021 Dec 09 (Print Publication: 2021).
DOI: 10.1002/ggn2.202100018
Abstrakt: Domestication of animals can lead to profound phenotypic modifications within short evolutionary time periods, and for many species behavioral selection is likely at the forefront of this process. Animal studies have strongly implicated that the gut microbiome plays a major role in host behavior and cognition through the microbiome-gut-brain axis. Consequently, herein, it is hypothesized that host gut microbiota may be one of the earliest phenotypes to change as wild animals were domesticated. Here, the gut microbiome community in two selected lines of red junglefowl that are selected for either high or low fear of humans up to eight generations is examined. Microbiota profiles reveal taxonomic differences in gut bacteria known to produce neuroactive compounds between the two selection lines. Gut-brain module analysis by means of genome-resolved metagenomics identifies enrichment in the microbial synthesis and degradation potential of metabolites associated with fear extinction and reduces anxiety-like behaviors in low fear fowls. In contrast, high fear fowls are enriched in gut-brain modules from the butyrate and glutamate pathways, metabolites associated with fear conditioning. Overall, the results identify differences in the composition and functional potential of the gut microbiota across selection lines that may provide insights into the mechanistic explanations of the domestication process.
Competing Interests: The authors declare no conflict of interest.
(© 2021 The Authors. Advanced Genetics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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