Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells.

Autor:	Tang YL; Medical College, Yangzhou University, Yangzhou, China., Zhu L; Medical College, Yangzhou University, Yangzhou, China., Yang HF; Medical College, Yangzhou University, Yangzhou, China., Tao Y; Medical College, Yangzhou University, Yangzhou, China., Lu W; Medical College, Yangzhou University, Yangzhou, China., Cheng H; Medical College, Yangzhou University, Yangzhou, China; hcheng@yzu.edu.cn.
Jazyk:	angličtina
Zdroj:	Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2023 Jan 01; Vol. 51 (1), pp. 77-83. Date of Electronic Publication: 2023 Jan 01 (Print Publication: 2023).
DOI:	10.15586/aei.v51i1.739
Abstrakt:	Nedd4 family interacting protein 1 ( Ndfip1 ) was first mentioned in an article in 2000. Since its discovery, related studies have shown that this protein is associated with apoptosis, neuroprotection, substance transport, ubiquitination, and immune regulation. It is noteworthy that the lack of Ndfip1 can lead to death in fetal mice. Researchers generally believe that the function of Ndfip1 is closely related to individual immune capacity and have published a large number of articles. However, a comprehensive classification of the immune regulatory function of Ndfip1 is still lacking. In this review, we will overview and discuss this new perspective, focusing on the role of Ndfip1 in the proliferation, differentiation, and cell activity of CD4 + T cells, CD8 + T cells, mast cells, and eosinophils. This review provides an updated summary of Ndfip1 , which will unveil novel therapeutic targets. Finally, the conclusion is that Ndfip1 mainly plays a negative regulatory role in immune cells by maintaining the stability of the immune response and limiting its overexpression. Competing Interests: The authors declare no potential conflicts of interest concerning the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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