Neonatal lupus erythematosus presenting as a non-bullous histiocytoid neutrophilic dermatosis.

Autor: Kozera EK; Department of Dermatology, Liverpool Hospital, Sydney, New South Wales, Australia., Langan R; Department of Anatomical Pathology, NSW Health Pathology, Liverpool Hospital, Sydney, New South Wales, Australia., Singh-Grewal D; Department of Rheumatology, Liverpool Hospital, Sydney, New South Wales, Australia., Sun HY; Faculty of Medicine and Health, UNSW, Kensington, New South Wales, Australia., Sebaratnam DF; Department of Dermatology, Liverpool Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, UNSW, Kensington, New South Wales, Australia., Henderson CJA; Department of Anatomical Pathology, NSW Health Pathology, Liverpool Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, UNSW, Kensington, New South Wales, Australia.; School of Medicine, Western Sydney University, Penrith, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2023 Jun; Vol. 50 (6), pp. 524-529. Date of Electronic Publication: 2023 Jan 24.
DOI: 10.1111/cup.14387
Abstrakt: Histopathologic findings in neonatal lupus erythematosus (NLE) are usually congruent with those of subacute cutaneous lupus erythematosus. However, neutrophilic dermatosis-type histopathologic features are being increasingly recognized in the literature including rare cases with variant histiocytoid morphology. We report the case of a 7-week-old male presenting with figurate erythema. His mother was found to have elevated anti-nuclear antibodies and was positive for anti-SSA/Ro, anti-SSB/La antibodies and Ro52 autoantibodies. The infant had a similar serological profile. Skin biopsy showed a histiocytoid interstitial infiltrate with mild lichenoid features, sparse neutrophils and mild leukocytoclasis. The histiocytoid infiltrate showed prominent CD68, CD163, and myeloperoxidase expression. Isolated clusters of CD123 + histiocytes were also present. This case highlights the rare finding of non-bullous neutrophilic dermatosis with histiocytoid change in neonatal lupus. In neonates presenting with figurate erythemas with morphological histiocytic change on biopsy, NLE should be considered as a differential diagnosis and investigated for accordingly.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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