Osteoporosis Assessment among Adults with Liver Cirrhosis.

Autor: Ionele CM; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Turcu-Stiolica A; Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Subtirelu MS; Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Ungureanu BS; Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Sas TN; Department of Radiology and Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Rogoveanu I; Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2022 Dec 25; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 25.
DOI: 10.3390/jcm12010153
Abstrakt: Osteopenic bone disease occurs frequently in patients with chronic liver cirrhosis, which most frequently presents with hepatic osteodystrophy. Thus, the relationship between nutritional status and bone mineral density has been poorly measured in liver cirrhosis. This single-center study consisted of a group of 70 patients diagnosed with liver cirrhosis. The nutritional status was evaluated with the Controlling Nutritional Status index, and volumetric vertebral bone mineral density was measured with quantitative computed tomography. Among the 70 patients included, osteopenia and osteoporosis were found in 71% and 24.3%, respectively. Malnutrition assessed with the Controlling Nutritional Status index was observed in 56 (80%) patients and was more frequent in alcoholic cirrhosis patients than viral cirrhosis patients (87.24% vs. 65.22%). Significant positive correlation with Controlling Nutritional Status score was found with Model for End-Stage Liver Disease (rho = 0.576, p-value < 0.0001), Child−Pugh score (rho = 0.670, p-value < 0.0001), International Normalized Ratio (rho = 0.517, p-value = 0.001), aspartate aminotransferase (rho = 0.293, p-value = 0.045), and bilirubin (rho =0.395, p-value = 0.02). Among the liver cirrhosis patients, 15 had osteoporosis and 49 had osteopenia at the lumbar spine (L1-L4 vertebrae), as determined by bone mass density via quantitative computed tomography. A non-significant relationship between Controlling Nutritional Status index-assessed nutritional status and bone mass density was documented. Regarding osteoporosis, no differences were found between the viral and alcohol types of liver cirrhosis patients (p-value = 0.870). Age, obesity, grade of varices, Child−Pugh score, and Model for End-Stage Liver Disease score were associated with osteoporosis in patients with liver cirrhosis.
Databáze: MEDLINE
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