| Autor: |
Ebbesen F; Department of Pediatrics, Aalborg University Hospital, 9000 Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark., Vreman HJ; Division of Neonatal and Development Medicine, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305-5101, USA., Hansen TWR; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, 0424 Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, 0450 Oslo, Norway. |
| Abstrakt: |
We have previously shown that the phototherapy of hyperbilirubinemic neonates using blue-green LED light with a peak wavelength of ~478 nm is 31% more efficient for removing unconjugated bilirubin from circulation than blue LED light with a peak wavelength of ~452 nm. Based on these results, we recommended that the phototherapy of hyperbilirubinemic newborns be practiced with light of ~480 nm. Aim: Identify and discuss the most prominent potential changes that have been observed in the health effects of phototherapy using either blue fluorescent- or blue LED light and speculate on the expected effects of changing to blue-green LED light phototherapy. Search the phototherapy literature using the terms neonate, hyperbilirubinemia, and phototherapy in the PubMed and Embase databases. Transitioning from blue fluorescent light to blue-green LED light will expose neonates to less light in the 400-450 nm spectral range, potentially leading to less photo-oxidation and geno-/cytotoxicity, reduced risk of cancer, and decreased mortality in extremely low-birthweight neonates. The riboflavin level may decline, and the increased production and retention of bronze pigments may occur in predisposed neonates due to enhanced lumirubin formation. The production of pre-inflammatory cytokines may rise. Hemodynamic responses and transepidermal water loss are less likely to occur. The risk of hyperthermia may decrease with the use of blue-green LED light and the risk of hypothermia may increase. Parent-neonate attachment and breastfeeding will be positively affected because of the shortened duration of phototherapy. The latter may also lead to a significant reduction in the cost of phototherapy procedures as well as the hospitalization process. |
