Impact of Mineralocorticoid Receptor Gene NR3C2 on the Prediction of Functional Classification of Left Ventricular Remodeling and Arrhythmia after Acute Myocardial Infarction.

Autor:	Braukyliene R; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania., Aldujeli A; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania.; Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania., Haq A; Minneapolis Heart Institute, 800 E 28th St Heart Hospital Minneapolis, Minneapolis, MN 55407, USA., Maciulevicius L; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania., Jankauskaite D; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania., Jurenas M; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania., Unikas R; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania., Zabiela V; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania., Lesauskaite V; Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania., Simonyte S; Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania., Zaliaduonytė D; Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.; Kaunas Region Lithuanian Society of Cardiology, Eiveniu Str. 2, 50009 Kaunas, Lithuania.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Dec 20; Vol. 20 (1). Date of Electronic Publication: 2022 Dec 20.
DOI:	10.3390/ijerph20010012
Abstrakt:	Background: The NR3C2 gene encodes the mineralocorticoid receptor, which is present on cardiomyocytes. Prior studies reported an association between the presence of NR3C2 single-nucleotide polymorphisms (SNPs) and an increased cortisol production during a stress response such as acute myocardial infarction (AMI), which may lead to adverse cardiac remodeling. Objective: To study the impact of the NR3C2 rs2070950, rs4635799 and rs5522 gene polymorphisms on left ventricular (LV) remodeling, rhythm and conduction disorders in AMI patients. Methods: A cohort of 301 AMI patients who underwent revascularization was included. SNPs of the NR3C2 gene (rs2070950, rs4635799 and rs5522) were evaluated. A total of 127 AMI patients underwent transthoracic echocardiography follow-up after 72 h and 6 months. Results: The rs2070950 GG genotype and rs4635799 TT genotype were most common in patients who had LV end-diastolic volume increase < 20% and the same or increased LV ejection fraction, indicating a possible protective effect of these SNPs. The rs5522 TT genotype was associated with a higher frequency of arrhythmias, while the presence of at least one rs5522 C allele was associated with a lower risk of arrhythmias. Conclusion: SNPs of the NR3C2 gene appear to correlate with better ventricular remodeling and a reduced rate of arrhythmias post-AMI, possibly by limiting the deleterious effects of cortisol on cardiomyocytes.
Databáze:	MEDLINE
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