A Novel Concept of Transperineal Focused Ultrasound Transducer for Prostate Cancer Local Deep Hyperthermia Treatments.

Autor: Guillemin PC; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland., Sinden D; Fraunhofer Institute for Digital Medicine MEVIS, Max-von-Laue Str. 2, 28359 Bremen, Germany., M'Rad Y; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland., Schwenke M; Fraunhofer Institute for Digital Medicine MEVIS, Max-von-Laue Str. 2, 28359 Bremen, Germany., Le Guevelou J; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.; Division of Radiation Oncology, Avenue de la Roseraie 53, University Hospitals of Geneva, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland., Uiterwijk JWE; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland., Lorton O; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland., Scheffler M; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.; Division of Radiology, Rue Gabrielle-Perret-Gentil 4, University Hospitals of Geneva, 1205 Geneva, Switzerland., Poletti PA; Division of Radiology, Rue Gabrielle-Perret-Gentil 4, University Hospitals of Geneva, 1205 Geneva, Switzerland., Jenne J; Fraunhofer Institute for Digital Medicine MEVIS, Max-von-Laue Str. 2, 28359 Bremen, Germany., Zilli T; Division of Radiation Oncology, Avenue de la Roseraie 53, University Hospitals of Geneva, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.; Radiation Oncology, Oncology Institute of Southern Switzerland, EOC, 6500 Bellinzona, Switzerland., Salomir R; Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.; Division of Radiology, Rue Gabrielle-Perret-Gentil 4, University Hospitals of Geneva, 1205 Geneva, Switzerland.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Dec 27; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 27.
DOI: 10.3390/cancers15010163
Abstrakt: Design, embodiment, and experimental study of a novel concept of extracorporeal phased array ultrasound transducer for prostate cancer regional deep hyperthermia treatments using a transperineal acoustic window is presented. An optimized design of hyperthermia applicator was derived from a modelling software where acoustic and thermal fields were computed based on anatomical data. Performance tests have been experimentally conducted on gel phantoms and tissues, under 3T MRI guidance using PRFS thermometry. Feedback controlled hyperthermia (ΔT = 5 °C during 20min) was performed on two ex vivo lamb carcasses with prostate mimicking pelvic tissue, to demonstrate capability of spatio-temporal temperature control and to assess potential risks and side effects. Our optimization approach yielded a therapeutic ultrasound transducer consisting of 192 elements of variable shape and surface, pseudo randomly distributed on 6 columns, using a frequency of 700 kHz. Radius of curvature was 140 mm and active water circulation was included for cooling. The measured focusing capabilities covered a volume of 24 × 50 × 60 mm 3 . Acoustic coupling of excellent quality was achieved. No interference was detected between sonication and MR acquisitions. On ex vivo experiments the target temperature elevation of 5 °C was reached after 5 min and maintained during another 15 min with the predictive temperature controller showing 0.2 °C accuracy. No significant temperature rise was observed on skin and bonny structures. Reported results represent a promising step toward the implementation of transperineal ultrasound hyperthermia in a pilot study of reirradiation in prostate cancer patients.
Databáze: MEDLINE
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