Impact of centralization of care for malignant peritoneal mesothelioma: A historical cohort study from the Dutch mesothelioma expert centers.

Autor: van Kooten JP; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. Electronic address: j.kooten@erasmusmc.nl., de Gooijer CJ; Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., von der Thüsen JH; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands., Brandt-Kerkhof ARM; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Albers AGJ; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Lahaye MJ; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Monkhorst K; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Burgers JA; Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Aerts JGJV; Department of Pulmonary Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Verhoef C; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Madsen EVE; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2023 Mar; Vol. 49 (3), pp. 611-618. Date of Electronic Publication: 2022 Oct 27.
DOI: 10.1016/j.ejso.2022.10.003
Abstrakt: Background: Malignant peritoneal mesothelioma (MPM) is a rare and aggressive cancer that has a poor prognosis. An earlier population-based study found that the majority of Dutch patients do not receive anti-cancer treatment. In 2015, Dutch Malignant Mesothelioma care was centralized in two expert centers. We reviewed treatment patterns at these centers, to assess the impact of centralization of MPM care in the Netherlands.
Methods: Data from all patients referred to the Dutch MPM expert centers from 2014 to 2020, were retrospectively collected. Descriptive statistics regarding referrals, patient and tumor characteristics, and treatment patterns were provided. Population-based incidence rates were provided by the Netherlands Cancer Registry.
Results: From 2014 to 2020, 78 patients were referred to the Dutch Mesothelioma expert centers, of whom 32 were female (41%). From 2014 to 2017, 27 patients were referred, whereas 51 patients were referred from 2018 to 2020. This represents about 24% and 61% of the estimated population incidence, respectively. Treatment patterns were comparable between both periods. Between 2014 and 2018, 33% of patients underwent surgery, 44% systemic therapy, and 22% received best supportive care (BSC), while this was 29%, 37%, and 33% respectively from 2018 to 2020.
Conclusion: Centralization of care for patients with MPM resulted in an increase of annual referrals to the Dutch mesothelioma expert centers. While population-based incidence did not change during the study period, the absolute number of patients receiving treatment at our centers did increase. This might be considered a first important step towards better treatment for patients with this fatal disease.
Competing Interests: Conflict of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: JB reports reimbursements for his institution (Netherlands Cancer Institute) outside the submitted work from Roche, AstraZeneca and Boehringer Ingelheim. JA reports grants outside the submitted work from Amphera and Roche, ownership interest (including patents) from Amphera, and advisory roles for Amphera, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, MSD and Roche, outside the submitted work. All other authors declare no conflict of interest.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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