Modeling environment through a general exposome factor in two independent adolescent cohorts.

Autor:	Moore TM; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Visoki E; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Argabright ST; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Didomenico GE; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Sotelo I; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Wortzel JD; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Naeem A; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Gur RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Gur RE; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA., Warrier V; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Guloksuz S; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., Barzilay R; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Lifespan Brain Institute of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, PA, USA.; Department of Child and Adolescent Psychiatry and Behavioral Science, Children's Hospital of Philadelphia (CHOP), Philadelphia, PA, USA.
Jazyk:	angličtina
Zdroj:	Exposome [Exposome] 2022 Dec 14; Vol. 2 (1), pp. osac010. Date of Electronic Publication: 2022 Dec 14 (Print Publication: 2022).
DOI:	10.1093/exposome/osac010
Abstrakt:	Exposures to perinatal, familial, social, and physical environmental stimuli can have substantial effects on human development. We aimed to generate a single measure that capture's the complex network structure of the environment (ie, exposome) using multi-level data (participant's report, parent report, and geocoded measures) of environmental exposures (primarily from the psychosocial environment) in two independent adolescent cohorts: The Adolescent Brain Cognitive Development Study (ABCD Study, N  = 11 235; mean age, 10.9 years; 47.7% females) and an age- and sex-matched sample from the Philadelphia Neurodevelopmental Cohort (PNC, N  = 4993). We conducted a series of data-driven iterative factor analyses and bifactor modeling in the ABCD Study, reducing dimensionality from 348 variables tapping to environment to six orthogonal exposome subfactors and a general (adverse) exposome factor. The general exposome factor was associated with overall psychopathology ( B  = 0.28, 95% CI, 0.26-0.3) and key health-related outcomes: obesity (odds ratio [OR] , 1.4; 95% CI, 1.3-1.5) and advanced pubertal development (OR, 1.3; 95% CI, 1.2-1.5). A similar approach in PNC reduced dimensionality of environment from 29 variables to 4 exposome subfactors and a general exposome factor. PNC analyses yielded consistent associations of the general exposome factor with psychopathology ( B  = 0.15; 95% CI, 0.13-0.17), obesity (OR, 1.4; 95% CI, 1.3-1.6), and advanced pubertal development (OR, 1.3; 95% CI, 1-1.6). In both cohorts, inclusion of exposome factors greatly increased variance explained in overall psychopathology compared with models relying solely on demographics and parental education (from <4% to >38% in ABCD; from <4% to >18.5% in PNC). Findings suggest that a general exposome factor capturing multi-level environmental exposures can be derived and can consistently explain variance in youth's mental and general health. (© The Author(s) 2022. Published by Oxford University Press.)
Databáze:	MEDLINE
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