Differences in Duodenal Mast Cell and Eosinophil Counts Between Patients With Functional Dyspepsia and Healthy People.

Autor: Hayatbakhsh Abbasi MM; Professor of Internal Medicine, Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran., Jafari E; Associate Professor, Pathology and stem cells Research Center, Kerman University of Medical Sciences, Kerman, Iran., Zahedi M; Professor of Internal Medicine, Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran., Darvish Moghaddam S; Professor of Internal Medicine, Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran., Taghizadeh A; Researcher, Pathology and stem cells Research Center, Kerman University of Medical Sciences, Kerman, Iran., Kharazmi N; Researcher, Pathology and stem cells Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Jazyk: angličtina
Zdroj: Middle East journal of digestive diseases [Middle East J Dig Dis] 2021 Oct; Vol. 13 (4), pp. 333-338. Date of Electronic Publication: 2021 Sep 13.
DOI: 10.34172/mejdd.2021.243
Abstrakt: BACKGROUND Functional dyspepsia is a common, troubling, and usually chronic disorder. Although the merit of using pathological assays has not been confirmed, medications affecting eosinophils may result in some improvements. Disseminated distribution of mast cells may also be an essential factor. Given the probable associations and lack of evidenced-based data, this study was conducted to comparatively investigate the number of eosinophils and mast cells in the duodenum in functional dyspepsia patients and healthy controls. METHODS In this case-control study, 150 consecutive subjects in Kerman, Iran, were enrolled in 2015 and 2016; the subjects consisted of 100 patients with functional dyspepsia and 50 asymptomatic healthy controls. Samples from the two groups were compared for the number of eosinophils, mast cells, and Helicobacter pylori presence by grasp biopsy. RESULTS The mean number of mast cells significantly differed between the groups (P = 0.001), but the eosinophil count was similar ( p > 0.05). Female gender, no opioid use, and H. pylori may increase mast cell count ( p < 0.05). CONCLUSION Overall, the mast cell count was significantly different between people with functional dyspepsia and people without it, but the eosinophil count in the two groups was similar.
Competing Interests: CONFLICT OF INTEREST The authors declare no conflict of interest related to this work
(© 2021 The Author(s).)
Databáze: MEDLINE
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