Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts.

Autor: Westbury LD; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Beaudart C; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Bruyère O; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Cauley JA; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Cawthon P; Research Institute, California Pacific Medical Center, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Cruz-Jentoft AJ; Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain., Curtis EM; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Ensrud K; Medicine and Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.; Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, USA., Fielding RA; Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA., Johansson H; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; Sahlgrenska Osteoporosis Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Kanis JA; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK., Karlsson MK; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmo, Lund University and Department of Orthopedics, Skane University Hospital, Malmo, Sweden., Lane NE; Division of Rheumatology, Department of Internal Medicine, UC Davis Health, Sacramento, CA, USA., Lengelé L; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Lorentzon M; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Mölndal, Sweden., McCloskey E; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; Centre for Integrated Research in Musculoskeletal Ageing (CIMA), Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK., Mellström D; Centre for Bone and Arthritis Research (CBAR), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Newman AB; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden., Orwoll E; Oregon Health & Science University, Portland, OR, USA., Reginster JY; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Ribom E; Department of Surgical Sciences, University of Uppsala, Uppsala, Sweden., Rosengren BE; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmo, Lund University and Department of Orthopedics, Skane University Hospital, Malmo, Sweden., Schousboe JT; Park Nicollet Clinic and HealthPartners Institute, Bloomington, MN, USA.; University of Minnesota, Minneapolis, MN, USA., Shiroma EJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., Harvey NC; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Dennison EM; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Victoria University of Wellington, Wellington, New Zealand., Cooper C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2023 Feb; Vol. 14 (1), pp. 565-575. Date of Electronic Publication: 2023 Jan 05.
DOI: 10.1002/jcsm.13160
Abstrakt: Background: The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health-related outcomes such as death are limited. We addressed this in a large multinational assembly of cohort studies that included information on lean mass, muscle strength, physical performance and health outcomes.
Methods: White men from the Health Aging and Body Composition (Health ABC) Study, Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, USA), the Hertfordshire Cohort Study (HCS) and the Sarcopenia and Physical impairment with advancing Age (SarcoPhAge) Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over courses of 2.4-6 m. Deaths were recorded and verified. Definitions of sarcopenia were as follows: EWGSOP2 (grip strength <27 kg and ALM index <7.0 kg/m 2 ), SDOC (grip strength <35.5 kg and gait speed <0.8 m/s) and Modified SDOC (grip strength <35.5 kg and gait speed <1.0 m/s). Cohen's kappa statistic was used to assess agreement between original definitions (EWGSOP2 and SDOC). Presence versus absence of sarcopenia according to each definition in relation to mortality risk was examined using Cox regression with adjustment for age and weight; estimates were combined across cohorts using random-effects meta-analysis.
Results: Mean (SD) age of participants (n = 9170) was 74.3 (4.9) years; 5929 participants died during a mean (SD) follow-up of 12.1 (5.5) years. The proportion with sarcopenia according to each definition was EWGSOP2 (1.1%), SDOC (1.7%) and Modified SDOC (5.3%). Agreement was weak between EWGSOP2 and SDOC (κ = 0.17). Pooled hazard ratios (95% CI) for mortality for presence versus absence of each definition were EWGSOP2 [1.76 (1.42, 2.18), I 2 : 0.0%]; SDOC [2.75 (2.28, 3.31), I 2 : 0.0%]; and Modified SDOC [1.93 (1.54, 2.41), I 2 : 58.3%].
Conclusions: There was low prevalence and poor agreement among recent sarcopenia definitions in community-dwelling cohorts of older white men. All indices of sarcopenia were associated with mortality. The strong relationship between sarcopenia and mortality, regardless of the definition, illustrates that identification of appropriate management and lifecourse intervention strategies for this condition is of paramount importance.
(© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.)
Databáze: MEDLINE
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