Mosquito vector competence for dengue is modulated by insect-specific viruses.

Autor: Olmo RP; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France., Todjro YMH; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Aguiar ERGR; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Department of Biological Sciences (DCB), Center of Biotechnology and Genetics (CBG), State University of Santa Cruz (UESC), Ilhéus, Brazil., de Almeida JPP; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Ferreira FV; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Armache JN; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Faria IJS; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Ferreira AGA; Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Minas Gerais, Brazil., Amadou SCG; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Silva ATS; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Souza KPR; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Vilela APP; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Babarit A; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France., Tan CH; Environmental Health Institute, Vector Biology and Control Division, National Environment Agency, Singapore, Singapore., Diallo M; Pôle de Zoologie Médicale, Institut Pasteur de Dakar, Dakar, Senegal., Gaye A; Pôle de Zoologie Médicale, Institut Pasteur de Dakar, Dakar, Senegal., Paupy C; Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle (MIVEGEC); Université de Montpellier, Institut de Recherche pour le Développement, CNRS, Montpellier, France., Obame-Nkoghe J; Laboratoire de Biologie Moléculaire et Cellulaire, Département de Biologie, Université des Sciences et Techniques de Masuku, Franceville, Gabon.; Écologie des Systèmes Vectoriels, Centre Interdisciplinaire de Recherches Médicales de Franceville, Franceville, Gabon., Visser TM; Laboratory of Entomology, Wageningen University and Research, Wageningen, the Netherlands., Koenraadt CJM; Laboratory of Entomology, Wageningen University and Research, Wageningen, the Netherlands., Wongsokarijo MA; Central Laboratory of the Bureau of Public Health, Paramaribo, Suriname., Cruz ALC; Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Prieto MT; Secretaria Municipal de Saúde, Seção de Controle de Vetores, Santos City Hall, Santos, Brazil., Parra MCP; Laboratory of Research in Virology, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Nogueira ML; Laboratory of Research in Virology, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.; Departament of Pathology, University of Texas Medical Branch, Galveston, TX, USA., Avelino-Silva V; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Cerqueira Cesar, Brazil., Mota RN; Health Surveillance (Zoonosis Control), Brumadinho City Hall, Brumadinho, Brazil., Borges MAZ; Center for Biological and Health Sciences, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Drumond BP; Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Kroon EG; Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Recker M; Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Penryn, UK.; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany., Sedda L; Lancaster Medical School, Lancaster University, Lancaster, UK., Marois E; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France., Imler JL; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France., Marques JT; Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. jtm@ufmg.br.; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France. jtm@ufmg.br.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2023 Jan; Vol. 8 (1), pp. 135-149. Date of Electronic Publication: 2023 Jan 05.
DOI: 10.1038/s41564-022-01289-4
Abstrakt: Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. Reasoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban Aedes mosquitoes collected from 12 countries worldwide. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most abundant in A. aegypti worldwide. Spatiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having DENV in wild A. aegypti mosquitoes when both HTV and PCLV were present. Using a mouse model in the laboratory, we showed that the presence of HTV and PCLV increased the ability of mosquitoes to transmit DENV and ZIKV to a vertebrate host. By transcriptomic analysis, we found that in DENV-infected mosquitoes, HTV and PCLV block the downregulation of histone H4, which we identify as an important proviral host factor in vivo.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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