Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.

Autor: Antonov YA; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Zhuravleva IL; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Bezrodnykh EA; A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia., Berezin BB; A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia., Kulikov SN; Kazan Scientific Research Institute of Epidemiology and Microbiology, Kazan, Russia; Kazan Federal University, Kazan, Russia., Tikhonov VE; A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia. Electronic address: tikhon@ineos.ac.ru.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2023 Feb 15; Vol. 302, pp. 120391. Date of Electronic Publication: 2022 Nov 25.
DOI: 10.1016/j.carbpol.2022.120391
Abstrakt: Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8. In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system. In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9. In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system. At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution. At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength. These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
Competing Interests: Declaration of competing interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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