Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals.

Autor: Ismail HY; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt. hamdy.yossef@cu.edu.eg., Hussein S; Department of Cytology and Histology , Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt., Shaker NA; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt., Rizk H; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt., Wally YR; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Jun; Vol. 30 (6), pp. 1770-1781. Date of Electronic Publication: 2023 Jan 05.
DOI: 10.1007/s43032-022-01152-1
Abstrakt: Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25-50% of infertility cases. According to several surveys, testicular degeneration can be caused by a variety of physical, chemical, and microbial causes. A stem cell is a non-specialized cell which is characterized by self-renewal by mitotic cell division and able to differentiate to specialized cells for the various tissues of the body. The data were obtained and analyzed from different databases (PubMed, Google Scholar, Egyptian Knowledge Bank, Elsevier, Medline, Embase, ProQuest, and BMC). This review discusses the causes, symptoms, and grades of testicular degeneration and the use of different types of stem cells in regeneration. And its conclusion based on previous researches and trials, MSCs are considered effective therapy for testicular degeneration.
(© 2022. The Author(s).)
Databáze: MEDLINE
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