Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™.

Autor: Younossi ZM; Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.; Inova Medicine Service Line, Inova Health System, Falls Church, Virginia, USA.; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA., Yu ML; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Yilmaz Y; Liver Research Unit, Institute of Gastroenterology, Marmara University, İstanbul, Turkey.; Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey., Alswat KA; Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Buti M; Liver Unit, Universitario Vall d'Hebron and CIBEREHD del Instituto Carlos III, Barcelona, Spain., Fernandez MIC; Institute of Gastroenterology, University of Medical Science, Havana, Cuba., Papatheodoridis G; Academic Department of Gastroenterology, General Hospital of Athens 'Laiko', Medical School of the National and Kapodistrian University of Athens, Athens, Greece., Hamid SS; Department of Medicine, Aga Khan University, Karachi, Pakistan., El-Kassas M; Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt., Chan WK; Department of Gastroenterology and Hepatology, University of Malaya, Kuala Lumpur, Malaysia., Duseja AK; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Gordon SC; Department of Hepatology and Gastroenterology, Henry Ford Hospital System, Wayne State University School of Medicine, Detroit, Michigan, USA., Eguchi Y; Loco Medical General Institute, Saga, Japan., Isakov VA; Division of Gastroenterology and Hepatology, Federal Research Center of Nutrition and Biotechnology, Moscow, Russia., Roberts SK; Department of Medicine, Monash University, Melbourne, Australia.; Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Australia., Fan JG; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Singal AK; University of South Dakota and Avera Transplant Institute, Sioux Falls, South Dakota, USA., Romero-Gómez M; Digestive Diseases Department, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain., Ahmed A; Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, USA., Ong J; College of Medicine, University of the Philippines, Manila, Philippines., Lam BP; Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.; Inova Medicine Service Line, Inova Health System, Falls Church, Virginia, USA.; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA., Younossi I; Center for Outcomes Research in Liver Diseases, Washington, DC, USA., Nader F; Center for Outcomes Research in Liver Diseases, Washington, DC, USA., Racila A; Center for Outcomes Research in Liver Diseases, Washington, DC, USA., Stepanova M; Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.; Inova Medicine Service Line, Inova Health System, Falls Church, Virginia, USA.; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA.; Center for Outcomes Research in Liver Diseases, Washington, DC, USA., Alqahtani S; Center for Outcomes Research in Liver Diseases, Washington, DC, USA.; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: Journal of viral hepatitis [J Viral Hepat] 2023 Apr; Vol. 30 (4), pp. 335-344. Date of Electronic Publication: 2023 Jan 11.
DOI: 10.1111/jvh.13800
Abstrakt: Chronic hepatitis B (CHB) infection is one of the most common causes of cirrhosis and liver cancer worldwide. Our aim was to assess clinical and patient-reported outcome (PRO) profile of CHB patients from different regions of the world using the Global Liver Registry. The CHB patients seen in real-world practices are being enrolled in the Global Liver Registry. Clinical and PRO (FACIT-F, CLDQ, WPAI) data were collected and compared to baseline data from CHB controls from clinical trials. The study included 1818 HBV subjects (48 ± 13 years, 58% male, 14% advanced fibrosis, 7% cirrhosis) from 15 countries in 6/7 Global Burden of Disease super-regions. The rates of advanced fibrosis varied (3-24%). The lowest PRO scores across multiple domains were in HBV subjects from the Middle East/North Africa (MENA), the highest - Southeast/East and South Asia. Subjects with advanced fibrosis had PRO impairment in 3 CLDQ domains, Activity of WPAI (p < 0.05). HBV subjects with superimposed fatty liver had more PRO impairments. In multivariate analysis adjusted for location, predictors of PRO impairment in CHB included female sex, advanced fibrosis, and non-hepatic comorbidities (p < 0.05). In comparison to Global Liver Registry patients, 242 controls from clinical trials had better PRO scores (Abdominal, Emotional, and Systemic scores of CLDQ, all domains of WPAI) (p < 0.05). In multivariate analysis with adjustment for location and clinicodemographic parameters, the associations of PROs with the enrollment setting (real-life Global Liver Registry vs. clinical trials) were no longer significant (all p > 0.10). The clinico-demographic portrait of CHB patients varies across regions of the world and enrollment settings. Advanced fibrosis and non-hepatic comorbidities are independently associated with PRO impairment in CHB patients.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje