Breakthrough Infections: Clinical Profile and Outcomes of COVID-19 Vaccinated and Unvaccinated People From a Tertiary Care Hospital.

Autor: Shahapur PR; Microbiology, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., Shahapur R; Dentistry, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., Bagali S; Microbiology, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., Karigoudar R; Microbiology, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., Wavare DS; Microbiology, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., P J; Microbiology, Shri B.M. Patil Medical College Hospital and Research Centre, BLDE (DU), Vijayapura, IND., Kandi V; Clinical Microbiology, Prathima Institute of Medical Sciences, Karimnagar, IND., Suvvari TK; Medicine and Surgery, Rangaraya Medical College, Kakinada, IND., Mittal RJ; Medicine, Gujarat Medical Education and Research Society Medical College, Gandhinagar, IND., Jadhav M; Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Jazyk: angličtina
Zdroj: Cureus [Cureus] 2022 Dec 01; Vol. 14 (12), pp. e32089. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2022).
DOI: 10.7759/cureus.32089
Abstrakt: Introduction Despite the availability of a vaccine and extensive vaccination, breakthrough infections are commonly noted, which is jeopardizing the vaccine-based protection against COVID-19. The present study aims to evaluate COVID-19 breakthrough infections and to compare the clinical profile and outcomes of the vaccinated and unvaccinated populations.  Methods A retrospective observational study was conducted for two months (March-April 2021), and all cases reported during the study period were included in the study. Socio-demographic details, COVID-19 profiles, clinical outcomes, vaccination statuses, and types of vaccine were collected from the patients. Further, COVID-19-positive samples were screened for lineages using next-generation sequencing (NGS). Results Of the total 103 patients included in the study, 79 (76.7%) were symptomatic and 24 (23.3%) were asymptomatic. Only 32% were vaccinated and 68% were unvaccinated. 29.2% were hospitalized due to COVID-19 and all of them were unvaccinated. The mortality among hospitalized patients was extremely high (60%). The time to positivity after complete vaccination was noted to be 37.09±23.74 days. The unvaccinated study participants showed lower Cycle threshold (Ct) values (E Gene/N Gene: 17.38±4.53) as compared to the vaccinated people (E Gene/N Gene: 22±4.25). The Delta (B. 1.1. 629) (76.7%) was the predominant variant among the study population followed by AY.4 (20.4%) and Kappa (2.9%) variants. Conclusion Although the vaccination does not restrict/avoid infection, it appears to protect the vaccinated people from severe forms of COVID-19. Also, the higher Ct values among vaccinated people indicate that the viral load among such people may be lower and, therefore, minimizes viral transmission.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2022, Shahapur et al.)
Databáze: MEDLINE
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