Mediterranean diet related metabolite profiles and cognitive performance.

Autor: Papandreou C; Pere Virgili Health Research Institute (IISPV), Reus, Spain. Electronic address: papchris10@gmail.com., Papagiannopoulos C; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Koutsonida M; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Kanellopoulou A; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Markozannes G; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Polychronidis G; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA., Tzakos AG; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, Greece; Institute of Materials Science and Computing, University Research Center of Ioannina (URCI), Ioannina, Greece., Fragkiadakis GA; Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University (HMU), Siteia, Greece., Evangelou E; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Institute of Biosciences, University Research Center of Ioannina, University of Ioannina, Ioannina, Greece., Ntzani E; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Institute of Biosciences, University Research Center of Ioannina, University of Ioannina, Ioannina, Greece; Center for Evidence-Based Medicine, Department of Health Services, Policy and Practice, School of Public Health, Brown University, Providence, USA., Tzoulaki I; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Aretouli E; Department of Psychology, School of Social Sciences, University of Ioannina, Ioannina, Greece; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsilidis KK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Electronic address: ktsilidi@uoi.gr.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2023 Feb; Vol. 42 (2), pp. 173-181. Date of Electronic Publication: 2022 Dec 22.
DOI: 10.1016/j.clnu.2022.12.012
Abstrakt: Background & Aims: Evidence suggests that adherence to the Mediterranean diet (MedDiet) affects human metabolism and may contribute to better cognitive performance. However, the underlying mechanisms are not clear.
Objective: We generated a metabolite profile for adherence to MedDiet and evaluated its cross-sectional association with aspects of cognitive performance.
Methods: A total of 1250 healthy Greek middle-aged adults from the Epirus Health Study cohort were included in the analysis. Adherence to the MedDiet was assessed using the 14-point Mediterranean Diet Adherence Screener (MEDAS); cognition was measured using the Trail Making Test, the Verbal Fluency test and the Logical Memory test. A targeted metabolite profiling (n = 250 metabolites) approach was applied, using a high-throughput nuclear magnetic resonance platform. We used elastic net regularized regressions, with a 10-fold cross-validation procedure, to identify a metabolite profile for MEDAS. We evaluated the associations of the identified metabolite profile and MEDAS with cognitive tests, using multivariable linear regression models.
Results: We identified a metabolite profile composed of 42 metabolites, mainly lipoprotein subclasses and fatty acids, significantly correlated with MedDiet adherence (Pearson r = 0.35, P-value = 5.5 × 10 -37 ). After adjusting for known risk factors and accounting for multiple testing, the metabolite profile and MEDAS were not associated with the cognitive tests.
Conclusions: A plasma metabolite profile related to better adherence to the MedDiet was not associated with the tested aspects of cognitive performance, in a middle-aged Mediterranean population.
Competing Interests: Conflict of interest The authors declare no conflicts of interest.
(Copyright © 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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