Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder.

Autor: Tan C; Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Nawaz H; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA., Lageman SK; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA., Cloud LJ; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA., Amara AW; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Newman BT; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA., Druzgal TJ; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA., Berman BD; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA., Mukhopadhyay N; Department of Biostatistics, Virginia Commonwealth University Health, Richmond, Virginia, USA., Barrett MJ; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Mar; Vol. 38 (3), pp. 474-479. Date of Electronic Publication: 2023 Jan 04.
DOI: 10.1002/mds.29306
Abstrakt: Background: Cholinergic nucleus 4 (Ch4) degeneration is associated with cognitive impairment in Parkinson's disease and dementia with Lewy bodies, but it is unknown if Ch4 degeneration is also present in isolated rapid eye movement sleep behavior disorder (iRBD).
Objective: The aim was to determine if there is evidence of Ch4 degeneration in patients with iRBD and if it is associated with cognitive impairment.
Methods: We analyzed the clinical and neuropsychological data of 35 iRBD patients and 35 age- and sex-matched healthy controls. Regional gray matter density (GMD) was calculated for Ch4 using probabilistic maps applied to brain magnetic resonance imaging (MRI).
Results: Ch4 GMD was significantly lower in the iRBD group compared to controls (0.417 vs. 0.441, P = 0.02). Ch4 GMD was also found to be a significant predictor of letter number sequencing (β-coefficient = 58.31, P = 0.026, 95% confidence interval [7.47, 109.15]), a measure of working memory.
Conclusions: iRBD is associated with Ch4 degeneration, and Ch4 degeneration in iRBD is associated with impairment in working memory. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
(© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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