COVID-19 international experience in paediatric patients with congenital heart disease.

Autor:	Yeh MJ; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA., Bergersen L; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA lisa.bergersen@childrens.harvard.edu., Gauvreau K; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA., Barry OM; The Congenital Heart Center, New York Presbyterian/Morgan Stanley Children's Hospital, New York, New York, USA., Batlivala SP; Department of Pediatrics, Cincinnati Children's Hospital Medical Center Heart Institute, Cincinnati, Ohio, USA., Bjornlund E; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA., Boe B; The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA., Caneo LF; Department of Cardiovascular Surgery, Instituto do Coracao do Hospital das Clinicas de Universidade de São Paulo, São Paulo, Brazil., Croti UA; Department of Pediatrics and Pediatric Surgery, CardioPedBrasil Children's Heart Center, Hospital da Criança e Maternidade FUNFARME/FAMERP São José do Rio Preto, São Paulo, Brazil., Doyle T; Division of Pediatric Cardiology, Monroe Carell Junior Children's Hospital at Vanderbilt University Medical Center, Nashville, Tennessee, USA., Furnaz S; Research Department, National Institute of Cardiovascular Disease, Karachi, Pakistan., Moraes RC; Dr. Carlos Alberto Studart Gomes Hospital, Hospital de Messejana, Fortaleza, Brazil., O'Byrne ML; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., de Oliveira Paes E; UTI Cardiopediátrica and Neonatal, Hospital do Coração (HCor), São Paulo, Brazil., Palacios-Macedo A; Department of Pediatric Cardiac Surgery, American British Cowdray Medical Center IAP, Mexico City, Mexico., Pechilkov D; Department of Pediatric Cardiology, Multiprofile Hospital for Active Treatment National Cardiology Hospital, Sofiâ, Bulgaria., Sandoval NF; Department of Cardiac Surgery, Fundación Cardioinfantil de Bogotá, Bogotá, Cundinamarca, Colombia., Sen S; Department of Pediatric Cardiology, Narayana Health SRCC Children's Hospital, Mumbai, Maharashtra, India., Stajevic M; Department for Pediatric Cardiothoracic Surgery, Mother and Children Health Institute, Belgrade, Serbia., Travessa MAF; Department of Cardiovascular Surgery, Hospital Gaspar Vianna, Belem, Brazil., Jenkins KJ; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2023 Apr 12; Vol. 109 (9), pp. 710-718. Date of Electronic Publication: 2023 Apr 12.
DOI:	10.1136/heartjnl-2022-321208
Abstrakt:	Objective: As COVID-19 continues to affect the global population, it is crucial to study the impact of the disease in vulnerable populations. This study of a diverse, international cohort aims to provide timely, experiential data on the course of disease in paediatric patients with congenital heart disease (CHD). Methods: Data were collected by capitalising on two pre-existing CHD registries, the International Quality Improvement Collaborative for Congenital Heart Disease: Improving Care in Low- and Middle-Income Countries and the Congenital Cardiac Catheterization Project on Outcomes. 35 participating sites reported data for all patients under 18 years of age with diagnosed CHD and known COVID-19 illness during 2020 identified at their institution. Patients were classified as low, moderate or high risk for moderate or severe COVID-19 illness based on patient anatomy, physiology and genetic syndrome using current published guidelines. Association of risk factors with hospitalisation and intensive care unit (ICU) level care were assessed. Results: The study included 339 COVID-19 cases in paediatric patients with CHD from 35 sites worldwide. Of these cases, 84 patients (25%) required hospitalisation, and 40 (12%) required ICU care. Age <1 year, recent cardiac intervention, anatomical complexity, clinical cardiac status and overall risk were all significantly associated with need for hospitalisation and ICU admission. A multivariable model for ICU admission including clinical cardiac status and recent cardiac intervention produced a c-statistic of 0.86. Conclusions: These observational data suggest risk factors for hospitalisation related to COVID-19 in paediatric CHD include age, lower functional cardiac status and recent cardiac interventions. There is a need for further data to identify factors relevant to the care of patients with CHD who contract COVID-19 illness. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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