Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study.

Autor:	Lindley CL; Huntsman Cancer Institute, Salt Lake City, Utah., Gigic B; Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Peoples AR; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah., Han CJ; University of Washington, School of Nursing, Seattle, Washington., Lin T; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah., Himbert C; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah., Warby CA; Huntsman Cancer Institute, Salt Lake City, Utah., Boehm J; Huntsman Cancer Institute, Salt Lake City, Utah., Hardikar S; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah., Ashworth A; Huntsman Cancer Institute, Salt Lake City, Utah., Schneider M; Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Ulrich A; Klinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Städtische Kliniken Neuss, Neuss, Germany., Schrotz-King P; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Figueiredo JC; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Li CI; Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Center, Seattle, Washington., Shibata D; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee., Siegel EM; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Toriola AT; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.; Siteman Cancer Center, St. Louis, Missouri., Ulrich CM; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah., Syrjala KL; Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Center, Seattle, Washington., Ose J; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Population Health Sciences, University of Utah, Utah.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Mar 06; Vol. 32 (3), pp. 363-370.
DOI:	10.1158/1055-9965.EPI-22-0882
Abstrakt:	Background: Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score. Methods: N = 315 patients (stage I-IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers. Results: Doubling of IL6 predicted future increased risk of overall distress [odds ratio (OR), 1.20; 95% confidence interval (CI), 1.02-1.41; P = 0.03]. VEGF-A-predicted future increased risk of high family strain (VEGF-A: OR, 1.21; 95% CI, 1.01-1.44; P = 0.04) and VEGF-D was associated with medical and financial demands (OR, 1.34; 95% CI, 1.01-1.74; P = 0.03). Conclusions: This is the first study to show that systemic biomarkers are significantly associated with future CTXD score. Distress was not measured at baseline; we cannot rule out ongoing associations of inflammation and distress throughout treatment versus a direct effect of inflammation on distress. Nonetheless, these data add to evidence that biobehavioral processes interact and that systemic biomarkers are associated with cancer-related distress one year after surgery. Impact: Exercise and diet interventions that lower systemic cytokine levels may impact longer-term CTXD score and improve quality of life of patients with colorectal cancer. (©2023 American Association for Cancer Research.)
Databáze:	MEDLINE
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