Cell-specific effects of the sole C. elegans Daughterless/E protein homolog, HLH-2, on nervous system development.

Autor:	Masoudi N; Department of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, NY 10027, USA., Schnabel R; Institute of Genetics, Technische Universität Braunschweig, 38106 Braunschweig, Germany., Yemini E; Department of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, NY 10027, USA.; University of Massachusetts, Department of Neurobiology, Worcester, MA 1605-2324, USA., Leyva-Díaz E; Department of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, NY 10027, USA., Hobert O; Department of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, NY 10027, USA.
Jazyk:	angličtina
Zdroj:	Development (Cambridge, England) [Development] 2023 Jan 01; Vol. 150 (1). Date of Electronic Publication: 2023 Jan 03.
DOI:	10.1242/dev.201366
Abstrakt:	Are there common mechanisms of neurogenesis used throughout an entire nervous system? We explored to what extent canonical proneural class I/II bHLH complexes are responsible for neurogenesis throughout the entire Caenorhabditis elegans nervous system. Distinct, lineage-specific proneural class II bHLH factors are generally thought to operate via interaction with a common, class I bHLH subunit, encoded by Daughterless in flies, the E proteins in vertebrates and HLH-2 in C. elegans. To eliminate function of all proneuronal class I/II bHLH complexes, we therefore genetically removed maternal and zygotic hlh-2 gene activity. We observed broad effects on neurogenesis, but still detected normal neurogenesis in many distinct neuron-producing lineages of the central and peripheral nervous system. Moreover, we found that hlh-2 selectively affects some aspects of neuron differentiation while leaving others unaffected. Although our studies confirm the function of proneuronal class I/II bHLH complexes in many different lineages throughout a nervous system, we conclude that their function is not universal, but rather restricted by lineage, cell type and components of differentiation programs affected. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2023. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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