Involvement of ERCC1 (rs3212986) and ERCC2 (rs1799793, rs13181) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso.

Autor: Adico MDW; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Zouré AA; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.; Biomedical Research Laboratory (LaReBio), Biomedical and Public Health Department, Institute for Research in Health Sciences (IRSS/CNRST), Ouagadougou, Burkina Faso., Sombié HK; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Kiendrebeogo TI; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Dabré S; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Amegnona LJ; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Bakyono BS; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Traoré L; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Ouedraogo TC; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Ouedraogo RA; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.; Centre Universitaire de Gaoua, NAZI BONI University, Dindéresso, Burkina Faso., Zohoncon TM; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.; Faculty of Medicine, Saint Thomas Aquinas University (USTA), Ouagadougou, Burkina Faso., Yonli AT; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Bayala B; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.; Ecole Normale Supérieur, Norbert ZONGO University, Koudougou, Burkina Faso., Bambara HA; Service of Oncology, University Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso., Djigma FW; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Simpore J; Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Toma, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.; Faculty of Medicine, Saint Thomas Aquinas University (USTA), Ouagadougou, Burkina Faso.
Jazyk: angličtina
Zdroj: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2023 Apr; Vol. 11 (4), pp. e2134. Date of Electronic Publication: 2023 Jan 03.
DOI: 10.1002/mgg3.2134
Abstrakt: Background: Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was to evaluate the involvement of two DNA repair genes, ERCC1 (rs3212986, GenBank NC_000073.9) and ERCC2 (rs1799793, rs13181, GenBank: NC_000019.10) in the occurrence of breast cancer in Burkina Faso.
Methods: This case-control study enrolled 128 participants including 64 patients and 64 healthy controls. Genotyping of polymorphisms were performed by real-time PCR and PCR-RFLP.
Results: The heterozygous AC genotype of the ERCC2rs13181 polymorphism was associated with the occurrence of breast cancer when the mutant allele is inherited under the dominant pattern (CC/AC vs AA; OR = 2.74, 95% IC (1.09-6.87); p = .028), but this association became insignificant after the Bonferroni correction (p = .156). No association was observed between ERCC1rs3212986 and ERCC2rs1799793 polymorphisms and breast cancer risk.
Conclusion: This study showed that the heterozygous genotype (CA) of the ERCC2rs13181 polymorphism may be associated with a risk of breast cancer.
(© 2023 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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