Efficacy of citalopram or amitriptyline versus no treatment in patients with functional chest pain.

Autor: Voulgaris T; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Lekakis V; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Vlachogiannakos J; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Kamberoglou D; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Orfanidou A; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Papatheodoridis G; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis)., Karamanolis G; Department of Gastroenterology, School of Medicine, National and Kapodistrian University of Athens, Greece (Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis).
Jazyk: angličtina
Zdroj: Annals of gastroenterology [Ann Gastroenterol] 2023 Jan-Feb; Vol. 36 (1), pp. 6-11. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.20524/aog.2023.0759
Abstrakt: Background: Functional chest pain (FCP) is characterized by the presence of chest pain of presumed esophageal origin, but with a negative workup on routine investigations, including ruling out gastroesophageal reflux disease (GERD). Antidepressants are frequently prescribed to treat FCP and are presumed to act as neuromodulators of visceral hypersensitivity. However, there is little evidence of their efficacy in patients with FCP. We retrospectively assessed the efficacy of citalopram or amitriptyline vs. no treatment in patients with FCP.
Methods: Esophageal diseases, including GERD, eosinophilic esophagitis and major esophageal motility disorders, were excluded. Thus, patients with established FCP according to Rome IV criteria were included in the study. Then, patients treated for at least 3 months with citalopram 20 mg, amitriptyline 50 mg, or observation were selected. The primary endpoint was complete disappearance or significant amelioration of symptoms at the end of treatment.
Results: Over a 5-year period, 102 patients (74 female; mean age 49±10 years) were diagnosed with FCP and were recognized to have received once daily citalopram (n=32), amitriptyline (n=34), or no treatment (n=36). After a 3-month follow up, improvement in chest pain was reported by 16 (47.1%) patients treated with citalopram, 18 (56.3%) patients treated with amitriptyline, and 4 (11.1%) patients without treatment (P=0.02 and 0.01 for no treatment vs. citalopram and amitriptyline therapy, respectively).
Conclusion: Both citalopram and amitriptyline are effective pharmacological options in the symptomatic relief of almost 50% patients with well characterized FCP.
Competing Interests: Conflict of Interest: None
(Copyright: © Hellenic Society of Gastroenterology.)
Databáze: MEDLINE
Externí odkaz: