Clonal hematopoiesis and inflammation - the perpetual cycle.

Autor: Avagyan S; Dana-Farber/Boston Children's Hospital Cancer and Blood Disorders Center, Boston, MA, USA. Electronic address: serine.avagyan@ucsf.edu., Zon LI; Boston Children's Hospital, Boston, MA 02215, USA; Howard Hughes Medical Institute, USA.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2023 Aug; Vol. 33 (8), pp. 695-707. Date of Electronic Publication: 2022 Dec 31.
DOI: 10.1016/j.tcb.2022.12.001
Abstrakt: Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact hematopoietic output, CH is associated with a heightened risk of progression to hematologic malignancies and with non-hematologic health manifestations, including cardiovascular disease and overall mortality. We focus on the evidence for the role of inflammation in establishing, maintaining and reciprocally being affected by CH. We describe the known pro-inflammatory signals associated with CH and preclinical studies that elucidated the cellular mechanisms involved. We review the evolving literature on early-onset CH in germline predisposition conditions and the possible role of immune dysregulation in this context.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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