Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia.

Autor:	Toller G; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Cobigo Y; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Callahan P; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Appleby BS; Case Western Reserve University, Cleveland, Ohio, USA., Brushaber D; Mayo Clinic, Rochester, Minnesota, USA., Domoto-Reilly K; University of Washington, Seattle, Washington, USA., Forsberg LK; Mayo Clinic, Rochester, Minnesota, USA., Ghoshal N; Washington University, St. Louis, Missouri, USA., Graff-Radford J; Mayo Clinic, Rochester, Minnesota, USA., Graff-Radford NR; Mayo Clinic, Jacksonville, Florida, USA., Grossman M; University of Pennsylvania, Philadelphia, PA, USA., Heuer HW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Kornak J; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Kremers W; Mayo Clinic, Rochester, Minnesota, USA., Lapid MI; Mayo Clinic, Rochester, Minnesota, USA., Leger G; University of California, San Diego, California, USA., Litvan I; University of California, San Diego, California, USA., Mackenzie IR; University of British Columbia, Vancouver, British Columbia, Canada., Pascual MB; Houston Methodist Hospital, Houston, Texas, USA., Ramos EM; University of California, Los Angeles, California, USA., Rascovsky K; University of Pennsylvania, Philadelphia, PA, USA., Rojas JC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Staffaroni AM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Tartaglia MC; University of Toronto, Ontario, Canada., Toga A; University of Southern California, Los Angeles, California, USA., Weintraub S; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Wszolek ZK; Mayo Clinic, Jacksonville, Florida, USA., Boeve BF; Mayo Clinic, Rochester, Minnesota, USA., Boxer AL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Rosen HJ; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Rankin KP; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jul; Vol. 19 (7), pp. 2842-2852. Date of Electronic Publication: 2023 Jan 02.
DOI:	10.1002/alz.12898
Abstrakt:	Introduction: Empathy relies on fronto-cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress. Methods: Four hundred thirty-one individuals with asymptomatic genetic FTD (n = 114), genetic and sporadic bvFTD (n = 317), and 163 asymptomatic non-carrier controls were enrolled. In sub-samples, we investigated empathy measured by the informant-based Interpersonal Reactivity Index (IRI) at each disease stage and over time (n = 91), and its correspondence to underlying atrophy (n = 51). Results: Empathic concern (estimate = 4.38, 95% confidence interval [CI] = 2.79, 5.97; p < 0.001) and perspective taking (estimate = 5.64, 95% CI = 3.81, 7.48; p < 0.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy. Discussion: Loss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials. (© 2022 the Alzheimer's Association.)
Databáze:	MEDLINE
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