Post COVID-19 irritable bowel syndrome.

Autor:	Marasco G; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Cremon C; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Barbaro MR; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy., Cacciari G; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Falangone F; Medical-Surgical Department of Clinical Sciences and Translational Medicine, University Sapienza Rome, Rome, Italy., Kagramanova A; Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation., Bordin D; Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation.; Tver State Medical University, Tver, Russian Federation.; Medicine and Dentistry, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia., Drug V; Gastroenterology, Grigore T Popa University of Medicine and Pharmacy Faculty of Medicine, Iasi, Romania., Miftode E; Department of Infectious Diseases, 'Grigore T Popa' University of Medicine and Pharmacy, Iasi, Romania., Fusaroli P; Gastroenterology Unit, University of Bologna, Imola, Italy., Mohamed SY; Internal Medicine Department, Zagazig University, Zagazig, Egypt., Ricci C; Gastroenterology Unit, University of Brescia, Brescia, Italy., Bellini M; Department of New Technologies and Translational Research in Medicine and Surgery, University of Pisa, Pisa, Italy., Rahman MM; Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh., Melcarne L; Gastroenterology Department, Hospital Universitario Parc Tauli, Sabadell, Cataluña, Spain., Santos J; Digestive System Research Unit, Hospital General Vall D'Hebron, Barcelona, Spain., Lobo B; Digestive System Research Unit, Hospital General Vall D'Hebron, Barcelona, Spain., Bor S; Ege University School of Medicine, Izmir, Turkey., Yapali S; Division of Gastroenterology, Acibadem University, Altunizade Acibadem Hospital, Istanbul, Turkey., Akyol D; Department of Infectious Diseases, Ege University, Izmir, Turkey., Sapmaz FP; Division of Gastroenterology, University of Health Sciences, Keciören Education and Research Hospital, Keciören, Turkey., Urun YY; Division of Gastroenterology, Eskisehir City Hospital, Eskisehir, Turkey., Eskazan T; Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Division of Gastroenterology, Turkey., Celebi A; Division of Gastroenterology, Kocaeli University, Kocaeli, Turkey., Kacmaz H; Division of Gastroenterology, Adiyaman Education and Research Hospital, Adiyaman, Turkey., Ebik B; Division of Gastroenterology, University of Health Sciences, Diyabakır Gazi Yasargil Education and Research Hospital, Diyarbakır, Turkey., Binicier HC; Division of Gastroenterology, Dokuz Eylül University, Izmir, Turkey., Bugdayci MS; Division of Gastroenterology, İstanbul Aydın University Florya Liv Hospital, Istanbul, Turkey., Yağcı MB; Division of Gastroenterology, Darıca Farabi Education and Research Hospital, Kocaeli, Turkey., Pullukcu H; Department of Infectious Diseases, Ege University, Izmir, Turkey., Kaya BY; Division of Gastroenterology, Eskisehir City Hospital, Eskisehir, Turkey., Tureyen A; Division of Gastroenterology, Eskisehir City Hospital, Eskisehir, Turkey., Hatemi İ; Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Division of Gastroenterology, Turkey., Koc ES; Division of Gastroenterology, Acibadem University, Altunizade Acibadem Hospital, Istanbul, Turkey., Sirin G; Division of Gastroenterology, Kocaeli University, Kocaeli, Turkey., Calıskan AR; Division of Gastroenterology, Adiyaman Education and Research Hospital, Adiyaman, Turkey., Bengi G; Division of Gastroenterology, Dokuz Eylül University, Izmir, Turkey., Alıs EE; Department of Infectious Diseases, İstanbul Aydın University Florya Liv Hospital, Istanbul, Turkey., Lukic S; Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Beograd, Beograd, Serbia., Trajkovska M; Clinic of Gastroenterohepatology, Skopje, Macedonia (the former Yugoslav Republic of)., Hod K; Research Division, Assuta Medical Center, Tel Aviv, Tel Aviv, Israel., Dumitrascu D; 2nd Medical Department of Internal Medicine, University of Medicine and Pharmacy, Cluj-Napoca, Romania., Pietrangelo A; Division of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy., Corradini E; Division of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy., Simren M; Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Sjölund J; Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Tornkvist N; Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Ghoshal UC; Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India., Kolokolnikova O; Medsi Clinical Hospital, Moscow, Russian Federation., Colecchia A; Division of Gastroenterology, University of Modena and Reggio Emilia, Modena, Italy., Serra J; CIBERehd, University Hospital Germans Trias i Pujol, Barcelona, Spain., Maconi G; Gastroenterology, L.Sacco University Hospital, Milan, Italy., De Giorgio R; Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Danese S; Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy., Portincasa P; Division of Internal Medicine 'A. Murri', Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy., Di Sabatino A; First Department of Internal Medicine, Università degli Studi di Pavia Facoltà di Medicina e Chirurgia, PV, Lombardia, Italy., Maggio M; Geriatric Clinic Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy., Philippou E; Department of Life and Health Sciences, Cyprus University of Nicosia, Nicosia, Cyprus., Lee YY; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia., Salvi D; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Venturi A; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy., Borghi C; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Zoli M; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Gionchetti P; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Viale P; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Stanghellini V; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Barbara G; Azienda Ospedaliero-Universitaria di Bologna IRCCS, Bologna, Emilia-Romagna, Italy giovanni.barbara@unibo.it.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Jazyk:	angličtina
Zdroj:	Gut [Gut] 2022 Dec 09. Date of Electronic Publication: 2022 Dec 09.
DOI:	10.1136/gutjnl-2022-328483
Abstrakt:	Objectives: The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction after hospitalisation for SARS-CoV-2 infection. Design: GI-COVID-19 is a prospective, multicentre, controlled study. Patients with and without COVID-19 diagnosis were evaluated on hospital admission and after 1, 6 and 12 months post hospitalisation. Gastrointestinal symptoms, anxiety and depression were assessed using validated questionnaires. Results: The study included 2183 hospitalised patients. The primary analysis included a total of 883 patients (614 patients with COVID-19 and 269 controls) due to the exclusion of patients with pre-existing gastrointestinal symptoms and/or surgery. At enrolment, gastrointestinal symptoms were more frequent among patients with COVID-19 than in the control group (59.3% vs 39.7%, p<0.001). At the 12-month follow-up, constipation and hard stools were significantly more prevalent in controls than in patients with COVID-19 (16% vs 9.6%, p=0.019 and 17.7% vs 10.9%, p=0.011, respectively). Compared with controls, patients with COVID-19 reported higher rates of irritable bowel syndrome (IBS) according to Rome IV criteria: 0.5% versus 3.2%, p=0.045. Factors significantly associated with IBS diagnosis included history of allergies, chronic intake of proton pump inhibitors and presence of dyspnoea. At the 6-month follow-up, the rate of patients with COVID-19 fulfilling the criteria for depression was higher than among controls. Conclusion: Compared with controls, hospitalised patients with COVID-19 had fewer problems of constipation and hard stools at 12 months after acute infection. Patients with COVID-19 had significantly higher rates of IBS than controls. Trial Registration Number: NCT04691895. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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