Decellularized matrix for repairing intervertebral disc degeneration: Fabrication methods, applications and animal models.
| Autor: | Qian H; Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China., He L; Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China., Ye Z; Department of Pathology, School of Basic Medical Sciences, Central South University, Changsha, China., Wei Z; Department of Burns and Plastic Surgery, The Affiliated Hospital of Zunyi Medical College, Zunyi, China., Ao J; Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China. |
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| Jazyk: | angličtina |
| Zdroj: | Materials today. Bio [Mater Today Bio] 2022 Dec 17; Vol. 18, pp. 100523. Date of Electronic Publication: 2022 Dec 17 (Print Publication: 2023). |
| DOI: | 10.1016/j.mtbio.2022.100523 |
| Abstrakt: | Intervertebral disc degeneration (IDD)-induced low back pain significantly influences the quality of life, placing a burden on public health systems worldwide. Currently available therapeutic strategies, such as conservative or operative treatment, cannot effectively restore intervertebral disc (IVD) function. Decellularized matrix (DCM) is a tissue-engineered biomaterial fabricated using physical, chemical, and enzymatic technologies to eliminate cells and antigens. By contrast, the extracellular matrix (ECM), including collagen and glycosaminoglycans, which are well retained, have been extensively studied in IVD regeneration. DCM inherits the native architecture and specific-differentiation induction ability of IVD and has demonstrated effectiveness in IVD regeneration in vitro and in vivo. Moreover, significant improvements have been achieved in the preparation process, mechanistic insights, and application of DCM for IDD repair. Herein, we comprehensively summarize and provide an overview of the roles and applications of DCM for IDD repair based on the existing evidence to shed a novel light on the clinical treatment of IDD. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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