Coronavirus disease 2019 (COVID-19) excess mortality outcomes associated with pandemic effects study (COPES): A systematic review and meta-analysis.

Autor:	Lu D; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Dhanoa S; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Cheema H; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Lewis K; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.; Division of Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada., Geeraert P; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Merrick B; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Vander Leek A; Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Sebastianski M; Alberta Strategy for Patient-Oriented Research Knowledge Translation Platform, University of Alberta, Edmonton, AB, Canada., Kula B; Division of Infectious Disease, Department of Medicine, Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada., Chaudhuri D; Division of Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada., Basmaji J; Division of Critical Care, Department of Medicine, Western University, London, ON, Canada., Agrawal A; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.; Division of General Internal Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada., Niven D; Department of Critical Care Medicine, Cumming School of Medicine, Alberta Health Services, University of Calgary, Calgary, AB, Canada., Fiest K; Department of Critical Care Medicine, Cumming School of Medicine, Alberta Health Services, University of Calgary, Calgary, AB, Canada., Stelfox HT; Department of Critical Care Medicine, Cumming School of Medicine, Alberta Health Services, University of Calgary, Calgary, AB, Canada., Zuege DJ; Department of Critical Care Medicine, Cumming School of Medicine, Alberta Health Services, University of Calgary, Calgary, AB, Canada., Rewa OG; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada.; School of Public Health, University of Alberta, Edmonton, AB, Canada., Bagshaw SM; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada.; School of Public Health, University of Alberta, Edmonton, AB, Canada., Lau VI; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, Alberta Health Services, University of Alberta, Edmonton, AB, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Dec 16; Vol. 9, pp. 999225. Date of Electronic Publication: 2022 Dec 16 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.999225
Abstrakt:	Background and Aim: With the Coronavirus Disease 2019 (COVID-19) pandemic continuing to impact healthcare systems around the world, healthcare providers are attempting to balance resources devoted to COVID-19 patients while minimizing excess mortality overall (both COVID-19 and non-COVID-19 patients). To this end, we conducted a systematic review (SR) to describe the effect of the COVID-19 pandemic on all-cause excess mortality (COVID-19 and non-COVID-19) during the pandemic timeframe compared to non-pandemic times. Methods: We searched EMBASE, Cochrane Database of SRs, MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Cochrane Controlled Trials Register (CENTRAL), from inception (1948) to December 31, 2020. We used a two-stage review process to screen/extract data. We assessed risk of bias using Newcastle-Ottawa Scale (NOS). We used Critical Appraisal and Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: Of 11,581 citations, 194 studies met eligibility. Of these studies, 31 had mortality comparisons ( n = 433,196,345 participants). Compared to pre-pandemic times, during the COVID-19 pandemic, our meta-analysis demonstrated that COVID-19 mortality had an increased risk difference (RD) of 0.06% (95% CI: 0.06-0.06% p < 0.00001). All-cause mortality also increased [relative risk (RR): 1.53, 95% confidence interval (CI): 1.38-1.70, p < 0.00001] alongside non-COVID-19 mortality (RR: 1.18, 1.07-1.30, p < 0.00001). There was "very low" certainty of evidence through GRADE assessment for all outcomes studied, demonstrating the evidence as uncertain. Interpretation: The COVID-19 pandemic may have caused significant increases in all-cause excess mortality, greater than those accounted for by increases due to COVID-19 mortality alone, although the evidence is uncertain. Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42020201256]. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lu, Dhanoa, Cheema, Lewis, Geeraert, Merrick, Vander Leek, Sebastianski, Kula, Chaudhuri, Basmaji, Agrawal, Niven, Fiest, Stelfox, Zuege, Rewa, Bagshaw and Lau.)
Databáze:	MEDLINE
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