Chemoradiotherapy with 3-weekly CDDP 80 mg/m 2 for head and neck squamous cell carcinoma: 5-year survival data from a phase 2 study.

Autor:	Otaki K; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Takahashi T; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Tanaka R; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Saijo K; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Omata J; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Yokoyama Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Shodo R; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Ueki Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Yamazaki K; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Ota H; Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan., Togashi T; Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan., Takahashi N; Department of Otorhinolaryngology, Nagaoka Red Cross Hospital, Niigata, Japan., Okabe R; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Matsuyama H; Department of Otorhinolaryngology, Niigata City General Hospital, Niigata, Japan., Horii A; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in surgery [Front Surg] 2022 Dec 16; Vol. 9, pp. 1035349. Date of Electronic Publication: 2022 Dec 16 (Print Publication: 2022).
DOI:	10.3389/fsurg.2022.1035349
Abstrakt:	Objective: The global standard for chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma is cisplatin 100 mg/m 2 administered once every three weeks, although cisplatin 80 mg/m 2 is also widely used as an alternative treatment to reduce adverse events in Japan. We aimed to assess the long-term survival outcomes and late adverse events associated with CCRT with a 3-weekly cisplatin dose of 80 mg/m 2 . Methods: A phase 2 study on CCRT with a 3-weekly cisplatin dose of 80 mg/m 2 was performed in 47 patients between April 2015 and December 2016 at four centers in Japan. Survival outcomes and late adverse events at 5 years after this phase 2 trial were investigated. Results: The median follow-up period was 61 months. The 5-year progression-free survival/overall survival of all 47 patients was 66.0%/76.6%, while that of patients with stage III, IV disease (UICC) was 65.6%/71.9%. Seventeen patients (36%) experienced dysphagia as a late adverse event. Univariate and multivariate analyses revealed a significant association between acute mucositis/low body mass index (BMI) during CCRT and late dysphagia. Conclusion: The survival outcomes of CCRT with a 3-weekly cisplatin dose of 80 mg/m 2 may be comparable to the previously reported dose of 100 mg/m 2 . Acute mucositis and low BMI at CCRT were risk factors for late dysphagia, indicating the importance of managing these conditions during CCRT to prevent late adverse events. Caution and care for acute mucositis and swallowing training in patients with low BMI may be important for preventing late-stage dysphagia. (© 2022 Otaki, Takahashi, Tanaka, Saijo, Omata, Yokoyama, Shodo, Ueki, Yamazaki, Ota, Togashi, Takahashi, Okabe, Matsuyama and Horii.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu