Magnetic resonance imaging for characterization of hepatocellular carcinoma metabolism.

Autor:	Wang L; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Yang JD; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.; Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Yoo CC; Office of the Medical Director 1st MRI, Los Angeles, CA, United States., Lai KKY; Department of Molecular Medicine, Beckman Research Institute of City of Hope and City of Hope Comprehensive Cancer Center, Duarte, CA, United States., Braun J; F. Widjaja Inflammatory Bowel Disease Institute, Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., McGovern DPB; F. Widjaja Inflammatory Bowel Disease Institute, Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Xie Y; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Pandol SJ; Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Lu SC; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Li D; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.; Department of Bioengineering, University of California, Los Angeles, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2022 Dec 15; Vol. 13, pp. 1056511. Date of Electronic Publication: 2022 Dec 15 (Print Publication: 2022).
DOI:	10.3389/fphys.2022.1056511
Abstrakt:	With a better understanding of the pathophysiological and metabolic changes in hepatocellular carcinoma (HCC), multiparametric and novel functional magnetic resonance (MR) and positron emission tomography (PET) techniques have received wide interest and are increasingly being applied in preclinical and clinical research. These techniques not only allow for non-invasive detection of structural, functional, and metabolic changes in malignant tumor cells but also characterize the tumor microenvironment (TME) and the interactions of malignant tumor cells with the TME, which has hypoxia and low pH, resulting from the Warburg effect and accumulation of metabolites produced by tumor cells and other cellular components. The heterogeneity and complexity of the TME require a combination of images with various parameters and modalities to characterize tumors and guide therapy. This review focuses on the value of multiparametric magnetic resonance imaging and PET/MR in evaluating the structural and functional changes of HCC and in detecting metabolites formed owing to HCC and the TME. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Wang, Yang, Yoo, Lai, Braun, McGovern, Xie, Pandol, Lu and Li.)
Databáze:	MEDLINE
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