Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons.

Autor: Jun S; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Ou X; Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China., Shi L; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Yu H; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Deng T; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Chen J; Core Facilities and Centers, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, China., Nie X; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Hao Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Shi Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Liu W; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Tian Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Wang S; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. wangsheng@hebmu.edu.cn.; Hebei Key Laboratory of Neurophysiology, Shijiazhuang, 050017, China. wangsheng@hebmu.edu.cn., Yuan F; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. yuanfphy@163.com.; Hebei Key Laboratory of Neurophysiology, Shijiazhuang, 050017, China. yuanfphy@163.com.
Jazyk: angličtina
Zdroj: Neuroscience bulletin [Neurosci Bull] 2023 Aug; Vol. 39 (8), pp. 1193-1209. Date of Electronic Publication: 2023 Jan 02.
DOI: 10.1007/s12264-022-01008-3
Abstrakt: The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activity. Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure (BP). Here, we investigated whether phenylethanolamine N-methyltransferase (PNMT)-expressing NTS (NTS PNMT ) neurons contribute to the control of BP. We demonstrate that photostimulation of NTS PNMT neurons has variable effects on BP. A depressor response was produced during optogenetic stimulation of NTS PNMT neurons projecting to the paraventricular nucleus of the hypothalamus, lateral parabrachial nucleus, and caudal ventrolateral medulla. Conversely, photostimulation of NTS PNMT neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia. In addition, genetic ablation of both NTS PNMT neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex. Overall, we revealed the neuronal phenotype- and circuit-specific mechanisms underlying the contribution of NTS PNMT neurons to the regulation of BP.
(© 2022. The Author(s).)
Databáze: MEDLINE
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