Perinatal risk factors for developmental coordination disorder in children born extremely preterm.

Autor: Bolk J; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Källén K; Centre for Reproductive Epidemiology, Lund University, Lund, Sweden., Farooqi A; Unit of Pediatrics, Institute of Clinical Sciences, University of Umeå, Umeå, Sweden., Hafström M; Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden.; Angered Hospital, Angered, Sweden., Fellman V; Department of Clinical Sciences, Lund, Pediatrics, Lund University, Lund, Sweden.; Folkhälsan Research Center, Helsinki, Finland.; Children's Hospital, Clinicum, University of Helsinki, Helsinki, Finland., Åden U; Karolinska University Hospital, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska institutet, Stockholm, Sweden., Serenius F; Unit of Pediatrics, Institute of Clinical Sciences, University of Umeå, Umeå, Sweden.; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2023 Apr; Vol. 112 (4), pp. 675-685. Date of Electronic Publication: 2023 Jan 12.
DOI: 10.1111/apa.16651
Abstrakt: Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD.
Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Second Edition. Perinatal risk factors were evaluated using multivariable logistic regression.
Results: DCD was present in 84/226 (37.2%) children. Of the risk factors known at 40 weeks gestation, independent and significant risk factors for DCD were: mother's age at delivery (odds ratio [OR] 1.73, 95% confidence interval [CI] 1.07-2.80); pre-eclampsia (2.79, 1.14-6.80); mother born in a non-Nordic country (2.23, 1.00-4.99); gestational age per week increase (0.70, 0.50-0.99) and retinopathy of prematurity (2.48, 1.26-4.87). Of factors known at discharge, postnatal steroids exposure (2.24, 1.13-4.46) and mechanical ventilation (1.76, 1.06-2.09) were independent risk factors when added to the model in separate analyses.
Conclusion: The risk of DCD in children born extremely preterm was multifactorial and associated with gestational age largely mediated by ROP, maternal factors, pre-eclampsia, administration of postnatal steroids and mechanical ventilation. These risk factors are common among children born extremely preterm, contributing to their high risk of DCD.
(© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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