Preoperative language tract integrity is a limiting factor in recovery from aphasia after glioma surgery.

Autor:	Prasse G; Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany. Electronic address: gordian.prasse@medizin.uni-leipzig.de., Meyer HJ; Department of Radiology, University Hospital Leipzig, 04103 Leipzig, Germany., Scherlach C; Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany., Maybaum J; Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany., Hoffmann A; Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany., Kasper J; Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany., Karl Fehrenbach M; Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany., Wilhelmy F; Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany., Meixensberger J; Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany., Hoffmann KT; Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany., Wende T; Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2023; Vol. 37, pp. 103310. Date of Electronic Publication: 2022 Dec 29.
DOI:	10.1016/j.nicl.2022.103310
Abstrakt:	Aphasia can occur in a broad range of pathological conditions that affect cortical or subcortical structures. Here we test the hypothesis that white matter integrity of language pathways assessed by preoperative diffusion tensor imaging (DTI) is associated with language performance and its recovery after glioma resection. 27 patients with preoperative DTI were included. Segmentation of the arcuate fascicle (AF), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF), the superior longitudinal fascicle (SLF), and the uncinate fascicle (UF) was performed with a fully-connected neural network (FCNN, TractSeg). Median fractional anisotropy (FA) was extracted from the resulting volumes as surrogate marker for white matter integrity and tested for correlation with clinical parameters. After correction for demographic data and multiple testing, preoperative white matter integrity of the IFOF, the ILF, and the UF in the left hemisphere were independently and significantly associated with aphasia three months after surgery. Comparison between patients with and without aphasia three months after surgery revealed significant differences in preoperative white matter integrity of the left AF (p = 0.021), left IFOF (p = 0.015), left ILF (p = 0.003), left SLF (p = 0.001, p = 0.021, p = 0.043 for respective sub-bundles 1-3), left UF (p = 0.041) and the right AF (p = 0.027). Preoperative assessment of white matter integrity of the language network by time-efficient MRI protocols and FCNN-driven segmentation may assist in the evaluation of postoperative rehabilitation potential in glioma patients. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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