Glycosyl Radical-Based Synthesis of C-Glycoamino Acids and C-Glycopeptides.

Autor: Wang C; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences, Lanzhou University, 199 West Donggang Road, Lanzhou, 730000, P.R. China.; Research Unit of Peptide Science, 2019RU066, Chinese Academy of Medical Sciences, 199 West Donggang Road, Lanzhou, 730000, P.R. China., Qi R; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences, Lanzhou University, 199 West Donggang Road, Lanzhou, 730000, P.R. China., Xu Z; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences, Lanzhou University, 199 West Donggang Road, Lanzhou, 730000, P.R. China.; Research Unit of Peptide Science, 2019RU066, Chinese Academy of Medical Sciences, 199 West Donggang Road, Lanzhou, 730000, P.R. China.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Apr 13; Vol. 29 (21), pp. e202203689. Date of Electronic Publication: 2023 Jan 30.
DOI: 10.1002/chem.202203689
Abstrakt: Radical-based reactions usually exhibit excellent functional-group compatibilities due to their mild initiation conditions. Glycosyl radical involved C-glycosylation modifications are important strategies to achieve highly regio- and chemoselective constructions of C-glycosidic bonds or C-glycoside linkages of peptides and proteins. In this Concept, we cover recent developments in glycosyl radical-based synthesis of unnatural amino acids and late-stage modification of peptides and proteins, and provide a preliminary outlook on the possible development of this direction in the future.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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