Inhibition of sPLA 2 enzyme activity by cell-permeable antioxidant EUK-8 and downregulation of p38, Akt, and p65 signals induced by sPLA 2 in inflammatory mouse paw edema model.
Autor: | Jayachandra K; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Gowda MDM; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Rudresha GV; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bengaluru, Karnataka, India., Manjuprasanna VN; Department of Hematology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Urs AP; Comprehensive Cancer Centre, The Ohio State University, Columbus, Ohio, USA., Nandana MB; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Bharatha M; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Jameel NM; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India., Vishwanath BS; Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka, India. |
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Jazyk: | angličtina |
Zdroj: | Journal of cellular biochemistry [J Cell Biochem] 2023 Feb; Vol. 124 (2), pp. 294-307. Date of Electronic Publication: 2022 Dec 31. |
DOI: | 10.1002/jcb.30366 |
Abstrakt: | The arachidonic acid (AA) metabolic pathway, plays a vital role in the production of eicosanoids by the action of pro-inflammatory secretory phospholipase A (© 2022 Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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