Efficacy of Biomarkers in Identifying Abnormal Echocardiogram in Multisystem Inflammatory Syndrome in Children.

Autor: Arora R; Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA., Sethuraman U; Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA., Merolla DM; Department of Sociology, Wayne State University, Detroit, MI, USA., Sanil Y; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA., Bharadwaj M; Pediatric Residency Program, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA., Kannikeswaran N; Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.
Jazyk: angličtina
Zdroj: Clinical pediatrics [Clin Pediatr (Phila)] 2023 Sep; Vol. 62 (8), pp. 908-913. Date of Electronic Publication: 2022 Dec 30.
DOI: 10.1177/00099228221145271
Abstrakt: Cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) is common and contributes to significant morbidity and mortality. We evaluated the efficacy of cardiac biomarkers in detection of an abnormal echocardiogram in MIS-C patients. A retrospective chart review of children ≤18 years diagnosed with MIS-C at our hospital was performed. Sensitivity and specificity of high-sensitivity troponin I (hs-TnI) and B-type natriuretic peptide (BNP) were estimated for an abnormal echocardiogram. Of the 83 patients with MIS-C, 33 (39.8%) had an abnormal echocardiogram. While BNP was more sensitive, hs-TnI >50 ng/L was more specific for detecting an abnormal echocardiogram. Compared with children who had normal hs-TnI levels (<17 ng/L), those with hs-TnI >50 ng/L were more likely to have an echocardiographic abnormality (relative risk: 4.9; 95% CI, 2.9-10.9). Children with abnormal BNP and/or troponin (especially greater than 3-fold the upper limit of normal) would benefit from an urgent echocardiogram in the emergency department.
Databáze: MEDLINE
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