Suppressive effects of bioactive herbal polysaccharides against different cancers: From mechanisms to translational advancements.

Autor: Farooqi AA; Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan., Rakhmetova V; Medical University of Astana, Kazakhstan., Kapanova G; Al-Farabi Kazakh National University, 71 al-Farabi Ave, Almaty 050040, Kazakhstan; Scientific Center of Anti-infectious Drugs, 75 a al-Faraby Ave, Almaty 050040, Kazakhstan., Mussakhanova A; Department of Public Health and Management, Astana Medical University, Astana, Kazakhstan., Tashenova G; Asfendiyarov Kazakh National Medical University, Kazakhstan; JSC 'Scientific Center of Pediatrics and Pediatric Surgery', Kazakhstan., Tulebayeva A; Asfendiyarov Kazakh National Medical University, Kazakhstan., Akhenbekova A; Asfendiyarov Kazakh National Medical University, Kazakhstan., Xu B; Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, 2000, Jintong Road, Tangjiawan, Zhuhai, Guangdong 519087, China. Electronic address: baojunxu@uic.edu.cn.
Jazyk: angličtina
Zdroj: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2023 Feb; Vol. 110, pp. 154624. Date of Electronic Publication: 2022 Dec 24.
DOI: 10.1016/j.phymed.2022.154624
Abstrakt: Background: Fueled by rapidly evolving comprehension of multifaceted nature of cancers, recently emerging preclinical and clinical data have supported researchers in the resolution of knowledge gaps to deepen the understanding of the molecular mechanisms. The extra-ordinary and bewildering chemical diversity encompassed by biologically active natural products continues to be of relevance to drug discovery. Accumulating evidence has spurred a remarkable evolution of concepts related to pharmacological target of oncogenic signaling pathways by polysaccharides in different cancers.
Purpose: The objective of the current review is to provide new insights into study progress on anticancer effects of bioactive herbal polysaccharides.
Methods: PubMed, Scopus, Web of Science, Embase, and other databases were searched for articles related to anticancer effects of polysaccharides. Searches were conducted to locate relevant publications published up to October 2022.
Results: Polysaccharides have been reported to pleiotropically modulate TGF/SMAD, BMP/SMAD, TLR4, mTOR, CXCR4 and VEGF/VEGFR cascades. We have also summarized how different polysaccharides regulated apoptosis and non-coding RNAs. Additionally, this mini-review describes increasingly sophisticated understanding related to polysaccharides mediated tumor suppressive and anti-metastatic effects in tumor-bearing mice. We have also provided an overview of the clinical trials related to chemopreventive role of polysaccharides.
Conclusion: Genomic and proteomic findings from these studies will facilitate 'next-generation' clinical initiatives in the prevention/inhibition of cancer.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: