Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study.

Autor: Wang L; Department of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.; Human Phenome Institute, Fudan University, Shanghai, China.; School of Life Sciences, Fudan University, Shanghai, China., Lin H; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.; Human Phenome Institute, Fudan University, Shanghai, China.; Institute for Metabolic Diseases, Fudan University, Shanghai, China., Zhao Z; Department of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Chen L; Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China., Wu L; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.; Institute for Metabolic Diseases, Fudan University, Shanghai, China., Liu T; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China., Li J; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China., Huang CC; School of Psychology and Cognitive Science, Institute of Cognitive Neuroscience, East China Normal University, Shanghai, China., Peng Y; Department of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Lo CZ; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China., Gao X; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.; Human Phenome Institute, Fudan University, Shanghai, China.; Institute for Metabolic Diseases, Fudan University, Shanghai, China.
Jazyk: angličtina
Zdroj: Human brain mapping [Hum Brain Mapp] 2023 Apr 01; Vol. 44 (5), pp. 2099-2108. Date of Electronic Publication: 2022 Dec 30.
DOI: 10.1002/hbm.26196
Abstrakt: White matter hyperintensity (WMH) is associated with vascular hemodynamic alterations and reflects white matter injury. To date, the sex difference of tract-specific WMH and the relationship between high blood pressure (BP) and tract-specific WMH remain unclear. We recruited 515 subjects from the Shanghai Changfeng study (range 53-89 years, mean age 67.33 years). Systolic and diastolic blood pressure (SBP and DBP) were collected and used to calculate pulse pressure (PP). Magnetic resonance T1 and T2 FLAIR images were acquired to measure WMH and calculate WMH index. The ANCOVA test was performed to test the difference between sexes, and the linear regression model was used to examine the associations between BP and WMH index. Men showed higher WMH index than women in all white matter tracts (p < .001, respectively) except for the bilateral superior longitudinal fasciculus (SLF) and its left temporal part (tSLF). High SBP and PP was associated with a lower WMH index on the left corticospinal tract (CST), SLF, tSLF and right cingulum in hippocampus (p ≤ .001, respectively) in women, while high DBP was associated with a higher WMH index on the bilateral CST (left p < .001; right p = .001), left inferior longitudinal fasciculus (p < .001) and inferior fronto-occipital fasciculus (p = .002) in men. Men tend to have more WMH compared to women. A high SBP/PP relates to a lower WMH burden in women. This suggests that women could benefit from higher blood pressure in older age.
(© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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