The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P 2 replenishment in response to TCR signaling during T cell development and survival.
Autor: | Lu W; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Helou YA; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Clade Therapeutics, Cambridge, MA, USA., Shrinivas K; NSF-Simons Center for Mathematical & Statistical Analysis of Biology, Harvard University, Cambridge, MA, USA., Liou J; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Au-Yeung BB; Division of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University, Atlanta, GA, USA., Weiss A; Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. Arthur.Weiss@ucsf.edu. |
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Jazyk: | angličtina |
Zdroj: | Nature immunology [Nat Immunol] 2023 Jan; Vol. 24 (1), pp. 136-147. Date of Electronic Publication: 2022 Dec 29. |
DOI: | 10.1038/s41590-022-01372-2 |
Abstrakt: | Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP (© 2022. The Author(s).) |
Databáze: | MEDLINE |
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